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Trex1 Gene Detail
Summary
  • Symbol
    Trex1
  • Name
    three prime repair exonuclease 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328317
    NCBI Gene: 22040
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108887000-108888791 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328317
 protein coding gene Chr9:108887000-108888802 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035323
 protein coding gene Chr9:111014749-111016550 (-)
A/J MGP_AJ_G0035302
 protein coding gene Chr9:106931037-106932838 (-)
AKR/J MGP_AKRJ_G0035234
 protein coding gene Chr9:109624554-109626355 (-)
BALB/cJ MGP_BALBcJ_G0035296
 protein coding gene Chr9:106631142-106632943 (-)
C3H/HeJ MGP_C3HHeJ_G0035006
 protein coding gene Chr9:110014225-110016026 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035816
 protein coding gene Chr9:114041291-114043092 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032714
 protein coding gene Chr9:104337546-104339327 (-)
CAST/EiJ MGP_CASTEiJ_G0034317
 protein coding gene Chr9:109987833-109989639 (-)
CBA/J MGP_CBAJ_G0034974
 protein coding gene Chr9:118054192-118055993 (-)
DBA/2J MGP_DBA2J_G0035135
 protein coding gene Chr9:106386264-106388065 (-)
FVB/NJ MGP_FVBNJ_G0035083
 protein coding gene Chr9:105206235-105208036 (-)
LP/J MGP_LPJ_G0035211
 protein coding gene Chr9:111200406-111202207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035122
 protein coding gene Chr9:119608222-119610023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035837
 protein coding gene Chr9:109893988-109895789 (-)
PWK/PhJ MGP_PWKPhJ_G0034024
 protein coding gene Chr9:106722769-106724654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033859
 protein coding gene Chr9:109959093-109960902 (-)
WSB/EiJ MGP_WSBEiJ_G0034438
 protein coding gene Chr9:109791339-109793140 (-)



Homology
more
  • Human Ortholog
    TREX1, three prime repair exonuclease 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TREX1, three prime repair exonuclease 1
  • Synonyms
    AGS1, CRV, DRN3, HERNS, RVCLS
  • Links
    NCBI Gene ID: 11277
    neXtProt AC: NX_Q9NSU2
    UniProt: Q9NSU2

  • Chr Location
    3p21.31; chr3:48465811-48467645 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Trex1 mouse models; 4 with human TREX1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 3 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    1 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice display premature death, cardiomyopathy, myocarditis, atrial thrombosis, and altered spleen morphology. Homozygotes for the D18N allele develop lupus-like disease with systemic inflammation, lymphoid hyperplasia, vasculitis, production of autoantibodies to dsDNA, and renal disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    118
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22040 NCBI Gene Model | MGI Sequence Detail 1792 C57BL/6J ±  kb
    transcript NM_011637 RefSeq | MGI Sequence Detail 1074 C57BL/6  
    polypeptide Q91XB0 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143232
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 27
      Phenotypes 48
    • Earliest
      J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
    • Latest
      J:340733 Ullah TR, et al., Pharmacological inhibition of TBK1/IKKepsilon blunts immunopathology in a murine model of SARS-CoV-2 infection. Nat Commun. 2023 Sep 18;14(1):5666
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory