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Lgals7 Gene Detail
Summary
  • Symbol
    Lgals7
  • Name
    lectin, galactose binding, soluble 7
  • Synonyms
    Galectin-7, Pig1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316742
    NCBI Gene: 16858
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28563278-28565709 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316742
 protein coding gene Chr7:28563258-28565711 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031965
 protein coding gene Chr7:27737456-27739887 (+)
A/J MGP_AJ_G0031943
 protein coding gene Chr7:27016411-27018842 (+)
AKR/J MGP_AKRJ_G0031875
 protein coding gene Chr7:27714596-27717027 (+)
BALB/cJ MGP_BALBcJ_G0031950
 protein coding gene Chr7:27173004-27175435 (+)
C3H/HeJ MGP_C3HHeJ_G0031669
 protein coding gene Chr7:28117908-28120339 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032414
 protein coding gene Chr7:28617843-28620274 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029466
 protein coding gene Chr7:28078505-28080956 (+)
CAST/EiJ MGP_CASTEiJ_G0031004
 protein coding gene Chr7:21414747-21417178 (+)
CBA/J MGP_CBAJ_G0031635
 protein coding gene Chr7:29935652-29938083 (+)
DBA/2J MGP_DBA2J_G0031787
 protein coding gene Chr7:26764830-26767261 (+)
FVB/NJ MGP_FVBNJ_G0031744
 protein coding gene Chr7:26853637-26856067 (+)
LP/J MGP_LPJ_G0031867
 protein coding gene Chr7:28037216-28039647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031780
 protein coding gene Chr7:29366381-29368812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032444
 protein coding gene Chr7:27193302-27195733 (+)
PWK/PhJ MGP_PWKPhJ_G0030729
 protein coding gene Chr7:21802189-21804620 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030562
 protein coding gene Chr7:18214442-18216867 (+)
WSB/EiJ MGP_WSBEiJ_G0031113
 protein coding gene Chr7:27570522-27572952 (+)



Homology
more
  • Human Ortholog
    LGALS7, galectin 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGALS7, galectin 7
  • Synonyms
    GAL7, LGALS7A
  • Links
    NCBI Gene ID: 3963
    neXtProt AC: NX_P47929

  • Chr Location
    19q13.2
  • Human Ortholog
    LGALS7B, galectin 7B
  • Synonyms
    Gal-7, GAL7, HKL-14, LGALS7, PI7
  • Links
    NCBI Gene ID: 653499
    neXtProt AC: NX_P47929
    UniProt: P47929

  • Chr Location
    19q13.2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to skin UVB irradiation with increased apoptosis and proliferation, and delayed wound healing due to reduced cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053522 Ensembl Gene Model | MGI Sequence Detail 2432 C57BL/6J ±  kb
    transcript ENSMUST00000138272 Ensembl | MGI Sequence Detail 657 Not Applicable  
    polypeptide ENSMUSP00000123110 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:49734 Magnaldo T, et al., Galectin-7, a marker of all types of stratified epithelia. Differentiation. 1998 Jul;63(3):159-68
    • Latest
      J:346445 Wu G, et al., Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1. Sci Rep. 2024 Mar 19;14(1):6625
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory