About   Help   FAQ
Krt34 Gene Detail
Summary
  • Symbol
    Krt34
  • Name
    keratin 34
  • Synonyms
    4733401E01Rik, Krt1-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309994
    NCBI Gene: 16672
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99928173-99932380 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309994
 protein coding gene Chr11:99928173-99932380 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019136
 protein coding gene Chr11:102782863-102787102 (-)
A/J MGP_AJ_G0019104
 protein coding gene Chr11:98443565-98447960 (-)
AKR/J MGP_AKRJ_G0019073
 protein coding gene Chr11:101486483-101492118 (-)
BALB/cJ MGP_BALBcJ_G0019078
 protein coding gene Chr11:98960300-98964507 (-)
C3H/HeJ MGP_C3HHeJ_G0018887
 protein coding gene Chr11:101682205-101687573 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019527
 protein coding gene Chr11:105948667-105953630 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017154
 protein coding gene Chr11:95896727-95900931 (-)
CAST/EiJ MGP_CASTEiJ_G0018441
 protein coding gene Chr11:102663008-102667230 (-)
CBA/J MGP_CBAJ_G0018856
 protein coding gene Chr11:110376355-110381557 (-)
DBA/2J MGP_DBA2J_G0018969
 protein coding gene Chr11:98007898-98021503 (-)
FVB/NJ MGP_FVBNJ_G0018958
 protein coding gene Chr11:97517271-97522353 (-)
LP/J MGP_LPJ_G0019037
 protein coding gene Chr11:103303253-103323462 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018989
 protein coding gene Chr11:110008805-110014354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019565
 protein coding gene Chr11:101861697-101866895 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0017996
 protein coding gene Chr11:101555309-101560564 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KRT34, keratin 34
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT34, keratin 34
  • Synonyms
    Ha-4, HA4, hHa4, K34, KRTHA4
  • Links
    NCBI Gene ID: 3885
    neXtProt AC: NX_O76011
    UniProt: O76011

  • Chr Location
    17q21.2; chr17:41377669-41383816 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    24
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16672 NCBI Gene Model | MGI Sequence Detail 4208 C57BL/6J ±  kb
    transcript NM_027563 RefSeq | MGI Sequence Detail 1609 ZRU/MplStud  
    polypeptide Q9D646 UniProt | EBI | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR002957 Keratin, type I
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 24

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1918063
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
    • Latest
      J:230728 Kumar V, et al., A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory