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Ltb4r1 Gene Detail
Summary
  • Symbol
    Ltb4r1
  • Name
    leukotriene B4 receptor 1
  • Synonyms
    BLT1, BLTR, mBLTR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309472
    NCBI Gene: 16995
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56003419-56005951 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309472
 protein coding gene Chr14:56002154-56005951 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021370
 protein coding gene Chr14:49808395-49812290 (+)
A/J MGP_AJ_G0021329
 protein coding gene Chr14:48819440-48826544 (+)
AKR/J MGP_AKRJ_G0021305
 protein coding gene Chr14:50570950-50574045 (+)
BALB/cJ MGP_BALBcJ_G0021333
 protein coding gene Chr14:48785402-48791041 (+)
C3H/HeJ MGP_C3HHeJ_G0021113
 protein coding gene Chr14:50260518-50263032 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021771
 protein coding gene Chr14:52305682-52308202 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019318
 protein coding gene Chr14:47188533-47190998 (+)
CAST/EiJ MGP_CASTEiJ_G0020632
 protein coding gene Chr14:46519259-46521743 (+)
CBA/J MGP_CBAJ_G0021080
 protein coding gene Chr14:53869244-53875845 (+)
DBA/2J MGP_DBA2J_G0021201
 protein coding gene Chr14:48539330-48541841 (+)
FVB/NJ MGP_FVBNJ_G0021183
 protein coding gene Chr14:47987858-47990363 (+)
LP/J MGP_LPJ_G0021275
 protein coding gene Chr14:50860508-50862979 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021207
 protein coding gene Chr14:53230692-53234296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021798
 protein coding gene Chr14:49752560-49755089 (+)
PWK/PhJ MGP_PWKPhJ_G0020379
 protein coding gene Chr14:45073294-45075812 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020207
 protein coding gene Chr14:45758273-45760789 (+)
WSB/EiJ MGP_WSBEiJ_G0020685
 protein coding gene Chr14:50036925-50039445 (+)



Homology
more
  • Human Ortholog
    LTB4R, leukotriene B4 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTB4R, leukotriene B4 receptor
  • Synonyms
    BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7
  • Links
    NCBI Gene ID: 1241
    neXtProt AC: NX_Q15722
    UniProt: Q15722

  • Chr Location
    14q12; chr14:24311450-24318036 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations cause impaired Ltb4-driven chemotaxis and adhesion. Homozygous null phenotypes include attenuated autoAb-driven arthritis, adoptive transfer-induced uveitis, airway hyperresponsiveness and Th2-type immune responses, and reduced eosinophil recruitment in induced peritonitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046908 Ensembl Gene Model | MGI Sequence Detail 2533 C57BL/6J ±  kb
    transcript ENSMUST00000057569 Ensembl | MGI Sequence Detail 1394 Not Applicable  
    polypeptide ENSMUSP00000051368 Ensembl | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 4
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 90
    • Earliest
      J:50101 Huang WW, et al., Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. J Exp Med. 1998 Sep 21;188(6):1063-74
    • Latest
      J:340632 Hernandez J, et al., n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout. Int J Mol Sci. 2023 Aug 31;24(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory