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Pcdh8 Gene Detail
Summary
  • Symbol
    Pcdh8
  • Name
    protocadherin 8
  • Synonyms
    1700080P15Rik, Papc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306800
    NCBI Gene: 18530
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:80004224-80008752 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 42.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306800
 protein coding gene Chr14:80004215-80008752 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021603
 protein coding gene Chr14:74922678-74927215 (-)
A/J MGP_AJ_G0021561
 protein coding gene Chr14:73050459-73054996 (-)
AKR/J MGP_AKRJ_G0021537
 protein coding gene Chr14:75222128-75226667 (-)
BALB/cJ MGP_BALBcJ_G0021567
 protein coding gene Chr14:72906651-72911188 (-)
C3H/HeJ MGP_C3HHeJ_G0021345
 protein coding gene Chr14:74948878-74953415 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022007
 protein coding gene Chr14:78082982-78087519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019546
 protein coding gene Chr14:70576672-70581216 (-)
CAST/EiJ MGP_CASTEiJ_G0020860
 protein coding gene Chr14:71725705-71749487 (-)
CBA/J MGP_CBAJ_G0021313
 protein coding gene Chr14:80598050-80602585 (-)
DBA/2J MGP_DBA2J_G0021437
 protein coding gene Chr14:72445874-72450412 (-)
FVB/NJ MGP_FVBNJ_G0021413
 protein coding gene Chr14:71784637-71789174 (-)
LP/J MGP_LPJ_G0021505
 protein coding gene Chr14:76008999-76013536 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021441
 protein coding gene Chr14:79250821-79255358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022030
 protein coding gene Chr14:74532334-74536869 (-)
PWK/PhJ MGP_PWKPhJ_G0020605
 protein coding gene Chr14:69244073-69248712 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020441
 protein coding gene Chr14:70482413-70505964 (-)
WSB/EiJ MGP_WSBEiJ_G0020915
 protein coding gene Chr14:74894142-74898679 (-)



Homology
more
  • Human Ortholog
    PCDH8, protocadherin 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCDH8, protocadherin 8
  • Synonyms
    ARCADLIN, PAPC
  • Links
    NCBI Gene ID: 5100
    neXtProt AC: NX_O95206
    UniProt: O95206

  • Chr Location
    13q14.3; chr13:52842889-52848641 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile, and do not exhibit any gross skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    25
  • cDNA Data
    25
  • Literature Summary
    19
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18530 NCBI Gene Model | MGI Sequence Detail 4529 C57BL/6J ±  kb
transcript NM_021543 RefSeq | MGI Sequence Detail 3991 ZRU/MplStud  
polypeptide Q7TSK3 UniProt | EBI | MGI Sequence Detail 1070 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 28
    Primer pair 1
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920747
References
more
  • Summaries
    All 51
    Developmental Gene Expression 19
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:50455 Strehl S, et al., Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14. Genomics. 1998 Oct 1;53(1):81-9
  • Latest
    J:344200 Inoue Y, et al., Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice. J Comp Neurol. 2022 Aug;530(11):2033-2055
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory