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Ifi27 Gene Detail
Summary
  • Symbol
    Ifi27
  • Name
    interferon, alpha-inducible protein 27
  • Synonyms
    1110013J02Rik, 2900026P10Rik, D12Ertd647e, Ifi27l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277180
    NCBI Gene: 52668
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103400470-103406498 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277180
 protein coding gene Chr12:103400448-103406504 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020050
 protein coding gene Chr12:105113432-105119694 (+)
A/J MGP_AJ_G0020006
 protein coding gene Chr12:101075943-101081929 (+)
AKR/J MGP_AKRJ_G0019982
 protein coding gene Chr12:103924699-103932111 (+)
BALB/cJ MGP_BALBcJ_G0019992
 protein coding gene Chr12:101430791-101437523 (+)
C3H/HeJ MGP_C3HHeJ_G0019794
 protein coding gene Chr12:104416929-104422952 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020441
 protein coding gene Chr12:108380626-108389074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018054
 protein coding gene Chr12:98116646-98122747 (+)
CAST/EiJ MGP_CASTEiJ_G0019340
 protein coding gene Chr12:99271730-99277808 (+)
CBA/J MGP_CBAJ_G0019766
 protein coding gene Chr12:112406828-112415185 (+)
DBA/2J MGP_DBA2J_G0019877
 protein coding gene Chr12:100599065-100605050 (+)
FVB/NJ MGP_FVBNJ_G0019866
 protein coding gene Chr12:99330568-99336833 (+)
LP/J MGP_LPJ_G0019953
 protein coding gene Chr12:104960630-104967797 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019906
 protein coding gene Chr12:115863453-115870282 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020470
 protein coding gene Chr12:103461326-103468724 (+)
PWK/PhJ MGP_PWKPhJ_G0019103
 protein coding gene Chr12:95158711-95164720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018899
 protein coding gene Chr12:97676667-97682787 (+)
WSB/EiJ MGP_WSBEiJ_G0019394
 protein coding gene Chr12:104347195-104354347 (+)



Homology
more
  • Human Ortholog
    IFI27, interferon alpha inducible protein 27
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI27, interferon alpha inducible protein 27
  • Synonyms
    FAM14D, ISG12, ISG12A, P27
  • Links
    NCBI Gene ID: 3429
    neXtProt AC: NX_P40305
    UniProt: P40305

  • Chr Location
    14q32.12; chr14:94104836-94116695 (+)  GRCh38
  • Human Ortholog
    IFI27L1, interferon alpha inducible protein 27 like 1
  • Synonyms
    FAM14B, ISG12C
  • Links
    NCBI Gene ID: 122509
    neXtProt AC: NX_Q96BM0
    UniProt: Q96BM0

  • Chr Location
    14q32.12; chr14:94081301-94103846 (+)  GRCh38
  • Human Ortholog
    IFI27L2, interferon alpha inducible protein 27 like 2
  • Synonyms
    FAM14A, ISG12B, TLH29
  • Links
    NCBI Gene ID: 83982
    neXtProt AC: NX_Q9H2X8
    UniProt: Q9H2X8

  • Chr Location
    14q32.12; chr14:94127779-94130253 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ifi27
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    10 strains or lines available
Mice homozygous for a knock-out allele exhibit protection from induced restenosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    3
  • cDNA Data
    156
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064215 Ensembl Gene Model | MGI Sequence Detail 6029 C57BL/6J ±  kb
transcript ENSMUST00000085065 Ensembl | MGI Sequence Detail 977 Not Applicable  
polypeptide ENSMUSP00000082142 Ensembl | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR038213 IFI6/IFI27-like domain superfamily
    IPR009311 Interferon alpha-inducible protein IFI6/IFI27-like
Molecular
Reagents
less
  • All nucleic 157
    cDNA 156
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915877, MGI:1925649
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:339248 Geng X, et al., PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response. Adv Sci (Weinh). 2022 Mar;9(7):e2103837
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory