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Cdk6 Gene Detail
Summary
  • Symbol
    Cdk6
  • Name
    cyclin dependent kinase 6
  • Synonyms
    Crk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277162
    NCBI Gene: 12571
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:3391485-3581008 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.04 cM, cytoband A2-A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    656 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277162
 protein coding gene Chr5:3391004-3581008 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029255
 protein coding gene Chr5:182886-336759 (+)
A/J MGP_AJ_G0029220
 protein coding gene Chr5:7155-218113 (+)
AKR/J MGP_AKRJ_G0029168
 protein coding gene Chr5:46089-216269 (+)
BALB/cJ MGP_BALBcJ_G0029236
 protein coding gene Chr5:189396-450738 (+)
C3H/HeJ MGP_C3HHeJ_G0028957
 protein coding gene Chr5:192060-386407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029686
 protein coding gene Chr5:353162-591119 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026928
 protein coding gene Chr5:14125-250652 (+)
CAST/EiJ MGP_CASTEiJ_G0028369
 protein coding gene Chr5:154810-392706 (+)
CBA/J MGP_CBAJ_G0028919
 protein coding gene Chr5:238189-483768 (+)
DBA/2J MGP_DBA2J_G0029068
 protein coding gene Chr5:120910-205937 (+)
FVB/NJ MGP_FVBNJ_G0029031
 protein coding gene Chr5:117397-280943 (+)
LP/J MGP_LPJ_G0029158
 protein coding gene Chr5:88827-375302 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029058
 protein coding gene Chr5:76497-293503 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029717
 protein coding gene Chr5:117173-341050 (+)
PWK/PhJ MGP_PWKPhJ_G0028090
 protein coding gene Chr5:191575-351979 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0028449
 protein coding gene Chr5:217052-365843 (+)



Homology
more
  • Human Ortholog
    CDK6, cyclin dependent kinase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK6, cyclin dependent kinase 6
  • Synonyms
    MCPH12, PLSTIRE
  • Links
    NCBI Gene ID: 1021
    neXtProt AC: NX_Q00534
    UniProt: Q00534

  • Chr Location
    7q21.2; chr7:92604921-92836573 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human CDK6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 7 alleles in 5 genetic backgrounds
    29 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    913
  • Tissues
    86
  • cDNA Data
    20
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040274 Ensembl Gene Model | MGI Sequence Detail 189524 C57BL/6J ±  kb
    transcript ENSMUST00000165117 Ensembl | MGI Sequence Detail 11525 Not Applicable  
    polypeptide ENSMUSP00000126024 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 22
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-2146, MGI:2140921, MGI:88503
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 45
      Diseases 1
      Gene Ontology 17
      Phenotypes 36
    • Earliest
      J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
    • Latest
      J:344186 Munoz-Gallardo MDM, et al., miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory