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Olr1 Gene Detail
Summary
  • Symbol
    Olr1
  • Name
    oxidized low density lipoprotein (lectin-like) receptor 1
  • Synonyms
    LOX-1, Scare1, SR-EI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261434
    NCBI Gene: 108078
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129462207-129484128 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261434
protein coding gene Chr6:129456113-129484312 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031349
protein coding gene Chr6:133152888-133175704 (-)
A/J MGP_AJ_G0031320
protein coding gene Chr6:128059723-128081936 (-)
AKR/J MGP_AKRJ_G0031248
protein coding gene Chr6:131555442-131577465 (-)
BALB/cJ MGP_BALBcJ_G0031327
protein coding gene Chr6:127703786-127725772 (-)
C3H/HeJ MGP_C3HHeJ_G0031051
protein coding gene Chr6:131753238-131775295 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031786
protein coding gene Chr6:136652112-136674021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028932
protein coding gene Chr6:126380404-126402433 (-)
CAST/EiJ MGP_CASTEiJ_G0030429
protein coding gene Chr6:131982964-132006113 (-)
CBA/J MGP_CBAJ_G0031011
protein coding gene Chr6:142029466-142057742 (-)
DBA/2J MGP_DBA2J_G0031168
protein coding gene Chr6:127015808-127038233 (-)
FVB/NJ MGP_FVBNJ_G0031118
protein coding gene Chr6:125895879-125919940 (-)
LP/J MGP_LPJ_G0031248
protein coding gene Chr6:133368941-133395770 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031156
protein coding gene Chr6:145883710-145906888 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031819
protein coding gene Chr6:131627474-131650113 (-)
PWK/PhJ MGP_PWKPhJ_G0030147
protein coding gene Chr6:125293486-125316388 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029976
protein coding gene Chr6:129640876-129667718 (-)
WSB/EiJ MGP_WSBEiJ_G0030517
protein coding gene Chr6:132053455-132076113 (-)



Homology
more
  • Human Ortholog
    OLR1, oxidized low density lipoprotein receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OLR1, oxidized low density lipoprotein receptor 1
  • Synonyms
    CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
  • Links
    NCBI Gene ID: 4973
    neXtProt AC: NX_P78380
    UniProt: P78380

  • Chr Location
    12p13.2; chr12:10158301-10176266 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with human OLR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030162 Ensembl Gene Model | MGI Sequence Detail 21922 C57BL/6J ±  kb
    transcript ENSMUST00000032265 Ensembl | MGI Sequence Detail 3572 Not Applicable  
    polypeptide ENSMUSP00000032265 Ensembl | MGI Sequence Detail 363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 12
      Primer pair 5
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 32
    • Earliest
      J:47339 Hoshikawa H, et al., High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1). Biochem Biophys Res Commun. 1998 Apr 28;245(3):841-6
    • Latest
      J:339300 Zhang Q, et al., Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15. Biochim Biophys Acta Mol Basis Dis. 2023 Jul 17;1869(8):166805

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory