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Fgf17 Gene Detail
Summary
  • Symbol
    Fgf17
  • Name
    fibroblast growth factor 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202401
    NCBI Gene: 14171
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70873643-70879708 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202401
 protein coding gene Chr14:70873643-70880064 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021547
 protein coding gene Chr14:65298102-65304158 (-)
A/J MGP_AJ_G0021506
 protein coding gene Chr14:63905144-63911209 (-)
AKR/J MGP_AKRJ_G0021482
 protein coding gene Chr14:65822766-65828829 (-)
BALB/cJ MGP_BALBcJ_G0021512
 protein coding gene Chr14:63668516-63674575 (-)
C3H/HeJ MGP_C3HHeJ_G0021289
 protein coding gene Chr14:65540303-65546366 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021951
 protein coding gene Chr14:68209754-68215814 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019491
 protein coding gene Chr14:61744478-61750600 (-)
CAST/EiJ MGP_CASTEiJ_G0020806
 protein coding gene Chr14:62133768-62139829 (-)
CBA/J MGP_CBAJ_G0021256
 protein coding gene Chr14:70364022-70370082 (-)
DBA/2J MGP_DBA2J_G0021379
 protein coding gene Chr14:63292008-63298147 (-)
FVB/NJ MGP_FVBNJ_G0021358
 protein coding gene Chr14:62720681-62726799 (-)
LP/J MGP_LPJ_G0021450
 protein coding gene Chr14:66540707-66552789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021387
 protein coding gene Chr14:69241693-69247829 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021975
 protein coding gene Chr14:65085036-65091099 (-)
PWK/PhJ MGP_PWKPhJ_G0020550
 protein coding gene Chr14:60060157-60066264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020383
 protein coding gene Chr14:61013024-61019122 (-)
WSB/EiJ MGP_WSBEiJ_G0020859
 protein coding gene Chr14:65396284-65402347 (-)



Homology
more
  • Human Ortholog
    FGF17, fibroblast growth factor 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF17, fibroblast growth factor 17
  • Synonyms
    FGF-13, FGF-17, HH20
  • Links
    NCBI Gene ID: 8822
    neXtProt AC: NX_O60258
    UniProt: O60258

  • Chr Location
    8p21.3; chr8:22039672-22048809 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FGF17 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are grossly normal at birth and apparently healthy at birth. However, there are tissue losses in the inferior colliculus and the anterior vermis of the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1022
  • Tissues
    225
  • cDNA Data
    13
  • Literature Summary
    90
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022101 Ensembl Gene Model | MGI Sequence Detail 6066 C57BL/6J ±  kb
    transcript ENSMUST00000022697 Ensembl | MGI Sequence Detail 1689 Not Applicable  
    polypeptide ENSMUSP00000022697 Ensembl | MGI Sequence Detail 216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 2
      cDNA 14
      Primer pair 7
      Other 13

      Microarray probesets 4
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 90
      Gene Ontology 3
      Phenotypes 22
    • Earliest
      J:46389 Hoshikawa M, et al., Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Biochem Biophys Res Commun. 1998 Mar 6;244(1):187-91
    • Latest
      J:330227 Iram T, et al., Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17. Nature. 2022 May;605(7910):509-515
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory