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Vps72 Gene Detail
Summary
  • Symbol
    Vps72
  • Name
    vacuolar protein sorting 72
  • Synonyms
    Tcfl1, YL-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202305
    NCBI Gene: 21427
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95018353-95030362 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202305
 protein coding gene Chr3:95018333-95030362 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027567
 protein coding gene Chr3:95803198-95816294 (+)
A/J MGP_AJ_G0027526
 protein coding gene Chr3:92849141-92861272 (+)
AKR/J MGP_AKRJ_G0027493
 protein coding gene Chr3:94988968-95002496 (+)
BALB/cJ MGP_BALBcJ_G0027538
 protein coding gene Chr3:92619501-92631545 (+)
C3H/HeJ MGP_C3HHeJ_G0027271
 protein coding gene Chr3:95272013-95284509 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027986
 protein coding gene Chr3:99370196-99383320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025326
 protein coding gene Chr3:89209471-89223111 (+)
CAST/EiJ MGP_CASTEiJ_G0026721
 protein coding gene Chr3:94557119-94571403 (+)
CBA/J MGP_CBAJ_G0027248
 protein coding gene Chr3:102974561-102989379 (+)
DBA/2J MGP_DBA2J_G0027387
 protein coding gene Chr3:92140806-92154144 (+)
FVB/NJ MGP_FVBNJ_G0027358
 protein coding gene Chr3:90211774-90223341 (+)
LP/J MGP_LPJ_G0027496
 protein coding gene Chr3:97093125-97106900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027385
 protein coding gene Chr3:109100067-109113526 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028040
 protein coding gene Chr3:94644081-94658318 (+)
PWK/PhJ MGP_PWKPhJ_G0026449
 protein coding gene Chr3:92019594-92031185 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026270
 protein coding gene Chr3:92939930-92953185 (+)
WSB/EiJ MGP_WSBEiJ_G0026803
 protein coding gene Chr3:95030987-95044286 (+)



Homology
more
  • Human Ortholog
    VPS72, vacuolar protein sorting 72 homolog
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS72, vacuolar protein sorting 72 homolog
  • Synonyms
    CFL1, Swc2, TCFL1, YL1, YL-1
  • Links
    NCBI Gene ID: 6944
    neXtProt AC: NX_Q15906
    UniProt: Q15906

  • Chr Location
    1q21.3; chr1:151176304-151195321 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    90
  • cDNA Data
    82
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21427 NCBI Gene Model | MGI Sequence Detail 12010 C57BL/6J ±  kb
transcript NM_009336 RefSeq | MGI Sequence Detail 1436 C57BL/6  
polypeptide Q62481 UniProt | EBI | MGI Sequence Detail 368 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    cDNA 82

    Microarray probesets 3
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 12
    Phenotypes 14
  • Earliest
    J:24182 Horikawa I, et al., Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. Biochem Biophys Res Commun. 1995 Mar 28;208(3):999-1007
  • Latest
    J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory