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Fam3d Gene Detail
Summary
  • Symbol
    Fam3d
  • Name
    FAM3 metabolism regulating signaling molecule D
  • Synonyms
    2310076N21Rik, EF-7, Oit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201784
    NCBI Gene: 18300
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:14091019-14120836 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 4.83 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201784
 protein coding gene Chr14:14091010-14120836 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020993
 protein coding gene Chr14:687225-719780 (-)
A/J MGP_AJ_G0020941
 protein coding gene Chr14:661671-691103 (-)
AKR/J MGP_AKRJ_G0020918
 protein coding gene Chr14:678774-707470 (-)
BALB/cJ MGP_BALBcJ_G0020943
 protein coding gene Chr14:659541-689396 (-)
C3H/HeJ MGP_C3HHeJ_G0020728
 protein coding gene Chr14:674620-704473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021377
 protein coding gene Chr14:709575-739817 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018946
 protein coding gene Chr14:1571615-1600949 (-)
CAST/EiJ MGP_CASTEiJ_G0020250
 protein coding gene Chr14:675080-707295 (-)
CBA/J MGP_CBAJ_G0020694
 protein coding gene Chr14:725268-760920 (-)
DBA/2J MGP_DBA2J_G0020817
 protein coding gene Chr14:639349-674608 (-)
FVB/NJ MGP_FVBNJ_G0020799
 protein coding gene Chr14:644963-674270 (-)
LP/J MGP_LPJ_G0020894
 protein coding gene Chr14:670265-705812 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020825
 protein coding gene Chr14:700223-732214 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021410
 protein coding gene Chr14:667097-695641 (-)
PWK/PhJ MGP_PWKPhJ_G0020002
 protein coding gene Chr14:672543-703527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019823
 protein coding gene Chr14:689815-720512 (-)
WSB/EiJ MGP_WSBEiJ_G0020308
 protein coding gene Chr14:679327-711256 (-)



Homology
more
  • Human Ortholog
    FAM3D, FAM3 metabolism regulating signaling molecule D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM3D, FAM3 metabolism regulating signaling molecule D
  • Synonyms
    EF7, OIT1
  • Links
    NCBI Gene ID: 131177
    neXtProt AC: NX_Q96BQ1
    UniProt: Q96BQ1

  • Chr Location
    3p14.2; chr3:58633946-58666834 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a targeted mutation exhibit emotion/affect abnormalities including decreased anxiety and depression responses. Mice homozygous for a null allele exhibit colitis by 1 year of age, increased sensitivity to chemically-induced colitis associated with high incidence of cancer, abnormal gut flora balance and males show decreased development of induced abdominal aortic aneurysm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    15
  • cDNA Data
    37
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021749 Ensembl Gene Model | MGI Sequence Detail 29818 C57BL/6J ±  kb
    transcript ENSMUST00000022269 Ensembl | MGI Sequence Detail 1253 Not Applicable  
    polypeptide ENSMUSP00000022269 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145775, MGI:2444732
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
    • Latest
      J:338854 Hu Y, et al., Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation. Metabolism. 2023 Jul 16;146:155661
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory