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Atp5if1 Gene Detail
Summary
  • Symbol
    Atp5if1
  • Name
    ATP synthase inhibitory factor subunit 1
  • Synonyms
    Atpif1, If1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196457
    NCBI Gene: 11983
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132257866-132260970 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196457
 protein coding gene Chr4:132257866-132262784 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028873
 protein coding gene Chr4:134695953-134699053 (-)
A/J MGP_AJ_G0028832
 protein coding gene Chr4:129093318-129096407 (-)
AKR/J MGP_AKRJ_G0028785
 protein coding gene Chr4:132726362-132729572 (-)
BALB/cJ MGP_BALBcJ_G0028855
 protein coding gene Chr4:129713110-129716202 (-)
C3H/HeJ MGP_C3HHeJ_G0028569
 protein coding gene Chr4:132991817-132994915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029297
 protein coding gene Chr4:139561307-139564592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026568
 protein coding gene Chr4:122170750-122173838 (-)
CAST/EiJ MGP_CASTEiJ_G0028002
 protein coding gene Chr4:131068843-131071942 (-)
CBA/J MGP_CBAJ_G0028535
 protein coding gene Chr4:143136492-143139590 (-)
DBA/2J MGP_DBA2J_G0028684
 protein coding gene Chr4:129514211-129517309 (-)
FVB/NJ MGP_FVBNJ_G0028651
 protein coding gene Chr4:128365310-128368407 (-)
LP/J MGP_LPJ_G0028785
 protein coding gene Chr4:134852103-134855195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028677
 protein coding gene Chr4:147727568-147730665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029335
 protein coding gene Chr4:133140099-133143196 (-)
PWK/PhJ MGP_PWKPhJ_G0027723
 protein coding gene Chr4:126207191-126210451 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027549
 protein coding gene Chr4:128987495-128990581 (-)
WSB/EiJ MGP_WSBEiJ_G0028082
 protein coding gene Chr4:133318117-133321206 (-)



Homology
more
  • Human Ortholog
    ATP5IF1, ATP synthase inhibitory factor subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP5IF1, ATP synthase inhibitory factor subunit 1
  • Synonyms
    ATPI, ATPIF1, ATPIP, IP
  • Links
    NCBI Gene ID: 93974
    neXtProt AC: NX_Q9UII2
    UniProt: Q9UII2

  • Chr Location
    1p35.3; chr1:28236109-28246906 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice exhibit normal growth and breeding but are protected from TAC-pressure overload and isoproterenol infusion-induced cardiac hypertrophy. A different KO reduces neutrophil levels and leads to resistance to DSS-induced colitis and increased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    52
  • cDNA Data
    190
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054428 Ensembl Gene Model | MGI Sequence Detail 3105 C57BL/6J ±  kb
    transcript ENSMUST00000067496 Ensembl | MGI Sequence Detail 539 Not Applicable  
    polypeptide ENSMUSP00000064282 Ensembl | MGI Sequence Detail 106 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 192
      cDNA 191
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:44646 Yamada E, et al., Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor. Immunology. 1997 Dec;92(4):571-6
    • Latest
      J:339700 Zhong G, et al., Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid. Biochim Biophys Acta Mol Basis Dis. 2023 Aug 7;1869(8):166820
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory