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Tnfsf12 Gene Detail
Summary
  • Symbol
    Tnfsf12
  • Name
    tumor necrosis factor (ligand) superfamily, member 12
  • Synonyms
    APO3L, DR3L, Tweak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196259
    NCBI Gene: 21944
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69577076-69586675 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196259
 protein coding gene Chr11:69577066-69586924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018550
 protein coding gene Chr11:70145262-70155097 (-)
A/J MGP_AJ_G0018518
 protein coding gene Chr11:67503199-67512767 (-)
AKR/J MGP_AKRJ_G0018487
 protein coding gene Chr11:69512943-69524360 (-)
BALB/cJ MGP_BALBcJ_G0018490
 protein coding gene Chr11:67812625-67822599 (-)
C3H/HeJ MGP_C3HHeJ_G0018303
 protein coding gene Chr11:69544728-69556287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018941
 protein coding gene Chr11:72266316-72278806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016586
 protein coding gene Chr11:64422038-64431148 (-)
CAST/EiJ MGP_CASTEiJ_G0017858
 protein coding gene Chr11:69786029-69797345 (-)
CBA/J MGP_CBAJ_G0018276
 protein coding gene Chr11:75502674-75513506 (-)
DBA/2J MGP_DBA2J_G0018385
 protein coding gene Chr11:67085665-67097038 (-)
FVB/NJ MGP_FVBNJ_G0018375
 protein coding gene Chr11:66728972-66739425 (-)
LP/J MGP_LPJ_G0018455
 protein coding gene Chr11:70713825-70723342 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018398
 protein coding gene Chr11:76093218-76104902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018983
 protein coding gene Chr11:69774569-69785553 (-)
PWK/PhJ MGP_PWKPhJ_G0017632
 protein coding gene Chr11:67735545-67745484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017422
 protein coding gene Chr11:69594511-69604036 (-)
WSB/EiJ MGP_WSBEiJ_G0017912
 protein coding gene Chr11:69446870-69458155 (-)



Homology
more
  • Human Ortholog
    TNFSF12, TNF superfamily member 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF12, TNF superfamily member 12
  • Synonyms
    APO3L, DR3LG, TNLG4A, TWEAK
  • Links
    NCBI Gene ID: 8742
    neXtProt AC: NX_O43508
    UniProt: O43508

  • Chr Location
    17p13.1; chr17:7548508-7557890 (+)  GRCh38
  • Human Ortholog
    TNFSF12-TNFSF13, TNFSF12-TNFSF13 readthrough
  • Synonyms
    TWE-PRIL
  • Links
    NCBI Gene ID: 407977
    neXtProt AC: NX_O43508

  • Chr Location
    17p13.1; chr17:7549058-7561601 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have increased numbers of natural killer cells, particulalry in secondary lymph organs. They display an enhanced inflammatory response, increased susceptibility to lipopolysaccharide, and increased tumor resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    34
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000097328 Ensembl Gene Model | MGI Sequence Detail 9600 C57BL/6J ±  kb
    transcript ENSMUST00000181810 Ensembl | MGI Sequence Detail 1435 Not Applicable  
    polypeptide ENSMUSP00000137972 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 42
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:343504 Guerrero-Hue M, et al., Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury. Biomed Pharmacother. 2023 Dec 31;169:115925
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory