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Rbm4 Gene Detail
Summary
  • Symbol
    Rbm4
  • Name
    RNA binding motif protein 4
  • Synonyms
    Lark1, Rbm4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100865
    NCBI Gene: 19653
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4834321-4843929 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.11 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100865
 protein coding gene Chr19:4834321-4844037 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024673
 protein coding gene Chr19:1679381-1690452 (-)
A/J MGP_AJ_G0024639
 protein coding gene Chr19:1601709-1611741 (-)
AKR/J MGP_AKRJ_G0024612
 protein coding gene Chr19:1645463-1654866 (-)
BALB/cJ MGP_BALBcJ_G0024639
 protein coding gene Chr19:1596741-1607194 (-)
C3H/HeJ MGP_C3HHeJ_G0024407
 protein coding gene Chr19:1648707-1658103 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025086
 protein coding gene Chr19:1731938-1743172 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022516
 protein coding gene Chr19:1530704-1540262 (-)
CAST/EiJ MGP_CASTEiJ_G0023879
 protein coding gene Chr19:1664725-1674898 (-)
CBA/J MGP_CBAJ_G0024378
 protein coding gene Chr19:1805115-1816335 (-)
DBA/2J MGP_DBA2J_G0024506
 protein coding gene Chr19:1565615-1575218 (-)
FVB/NJ MGP_FVBNJ_G0024473
 protein coding gene Chr19:1589846-1599800 (-)
LP/J MGP_LPJ_G0024592
 protein coding gene Chr19:1687015-1697432 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024503
 protein coding gene Chr19:1710697-1721138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025134
 protein coding gene Chr19:1641574-1650973 (-)
PWK/PhJ MGP_PWKPhJ_G0023625
 protein coding gene Chr19:1617483-1627214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023430
 protein coding gene Chr19:1629760-1639225 (-)
WSB/EiJ MGP_WSBEiJ_G0023941
 protein coding gene Chr19:1637159-1646497 (-)



Homology
more
  • Human Ortholog
    RBM4, RNA binding motif protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM4, RNA binding motif protein 4
  • Synonyms
    LARK, RBM4A, ZCCHC21, ZCRB3A
  • Links
    NCBI Gene ID: 5936
    neXtProt AC: NX_Q9BWF3
    UniProt: Q9BWF3

  • Chr Location
    11q13.2; chr11:66638667-66668380 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced postnatal body weight, decreased insulin levels, smaller pancreatic islets and impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    139
  • cDNA Data
    13
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000094936 Ensembl Gene Model | MGI Sequence Detail 9609 C57BL/6J ±  kb
    transcript ENSMUST00000179189 Ensembl | MGI Sequence Detail 1411 Not Applicable  
    polypeptide ENSMUSP00000137174 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034897 RBM4, RNA recognition motif 1
      IPR034898 RBM4, RNA recognition motif 2
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR001878 Zinc finger, CCHC-type
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:40153 Jackson FR, et al., A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans. Genomics. 1997 May 1;41(3):444-52
    • Latest
      J:340400 Tsai YY, et al., Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Commun Biol. 2023 Sep 5;6(1):910
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory