About   Help   FAQ
Myt1 Gene Detail
Summary
  • Symbol
    Myt1
  • Name
    myelin transcription factor 1
  • Synonyms
    mKIAA0835, Nzf2, NZF-2a, NZF-2b, Nztf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100535
    NCBI Gene: 17932
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:181405125-181469590 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.77 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100535
 protein coding gene Chr2:181405099-181469590 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027037
 protein coding gene Chr2:188386420-188457804 (+)
A/J MGP_AJ_G0027003
 protein coding gene Chr2:180612766-180679301 (+)
AKR/J MGP_AKRJ_G0026973
 protein coding gene Chr2:186034923-186106715 (+)
BALB/cJ MGP_BALBcJ_G0027011
 protein coding gene Chr2:181097409-181162412 (+)
C3H/HeJ MGP_C3HHeJ_G0026753
 protein coding gene Chr2:186377270-186445797 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027457
 protein coding gene Chr2:193824272-193898961 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024821
 protein coding gene Chr2:171296236-171361954 (+)
CAST/EiJ MGP_CASTEiJ_G0026212
 protein coding gene Chr2:184663221-184732411 (+)
CBA/J MGP_CBAJ_G0026730
 protein coding gene Chr2:200861055-200938644 (+)
DBA/2J MGP_DBA2J_G0026867
 protein coding gene Chr2:179715761-179785108 (+)
FVB/NJ MGP_FVBNJ_G0026833
 protein coding gene Chr2:178341976-178410028 (+)
LP/J MGP_LPJ_G0026969
 protein coding gene Chr2:188404686-188476939 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026853
 protein coding gene Chr2:203398912-203469670 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027517
 protein coding gene Chr2:186017247-186083036 (+)
PWK/PhJ MGP_PWKPhJ_G0025948
 protein coding gene Chr2:177247594-177313445 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025748
 protein coding gene Chr2:182507722-182571950 (+)
WSB/EiJ MGP_WSBEiJ_G0026284
 protein coding gene Chr2:186990309-187060952 (+)



Homology
more
  • Human Ortholog
    MYT1, myelin transcription factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYT1, myelin transcription factor 1
  • Synonyms
    C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2H2C1, ZC2HC4A
  • Links
    NCBI Gene ID: 4661
    neXtProt AC: NX_Q01538
    UniProt: Q01538

  • Chr Location
    20q13.33; chr20:64102394-64242253 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1049
  • Tissues
    163
  • cDNA Data
    17
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010505 Ensembl Gene Model | MGI Sequence Detail 64466 C57BL/6J ±  kb
    transcript ENSMUST00000081125 Ensembl | MGI Sequence Detail 5327 Not Applicable  
    polypeptide ENSMUSP00000079900 Ensembl | MGI Sequence Detail 1169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 18
      Primer pair 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38473, MGI:109428
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 33
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
    • Latest
      J:336866 Puelles L, et al., The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory