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Fgf10 Gene Detail
Summary
  • Symbol
    Fgf10
  • Name
    fibroblast growth factor 10
  • Synonyms
    AEY17, FGF-10, Gsfaey17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099809
    NCBI Gene: 14165
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:118851199-118928651 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 67.14 cM, cytoband A3-A4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    811 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099809
 protein coding gene Chr13:118806327-118928651 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020968
 protein coding gene Chr13:121667437-121795770 (+)
A/J MGP_AJ_G0020918
 protein coding gene Chr13:116734285-116863621 (+)
AKR/J MGP_AKRJ_G0020893
 protein coding gene Chr13:120193764-120317860 (+)
BALB/cJ MGP_BALBcJ_G0020918
 protein coding gene Chr13:117436150-117562237 (+)
C3H/HeJ MGP_C3HHeJ_G0020707
 protein coding gene Chr13:120014407-120142584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021354
 protein coding gene Chr13:125165469-125311590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018923
 protein coding gene Chr13:111792749-111917686 (+)
CAST/EiJ MGP_CASTEiJ_G0020226
 protein coding gene Chr13:119863115-119998261 (+)
CBA/J MGP_CBAJ_G0020669
 protein coding gene Chr13:130035259-130164599 (+)
DBA/2J MGP_DBA2J_G0020792
 protein coding gene Chr13:116352136-116474548 (+)
FVB/NJ MGP_FVBNJ_G0020776
 protein coding gene Chr13:114974761-115099975 (+)
LP/J MGP_LPJ_G0020868
 protein coding gene Chr13:121614039-121743136 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020804
 protein coding gene Chr13:130603032-130753574 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021390
 protein coding gene Chr13:119685145-119808747 (+)
PWK/PhJ MGP_PWKPhJ_G0019979
 protein coding gene Chr13:115230236-115360384 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019802
 protein coding gene Chr13:116104565-116229666 (+)
WSB/EiJ MGP_WSBEiJ_G0020284
 protein coding gene Chr13:120371429-120496804 (+)



Homology
more
  • Human Ortholog
    FGF10, fibroblast growth factor 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF10, fibroblast growth factor 10
  • Synonyms
    LADD3
  • Links
    NCBI Gene ID: 2255
    neXtProt AC: NX_O15520
    UniProt: O15520

  • Chr Location
    5p12; chr5:44300247-44389706 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fgf10 mouse models; 2 with human FGF10 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    172 phenotypes from 9 alleles in 13 genetic backgrounds
    43 phenotypes from multigenic genotypes
    7 images
    171 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants die at birth with multiple abnormalities including absence of lungs, severely truncated limbs, open eyelids, incomplete external genitalia, arrested pancreatic development, lack of mammary glands and impaired epidermal development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    221
  • GO References
    60
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1877
  • Tissues
    615
  • cDNA Data
    38
  • Literature Summary
    532
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14165 NCBI Gene Model | MGI Sequence Detail 77453 C57BL/6J ±  kb
    transcript NM_008002 RefSeq | MGI Sequence Detail 4150 ZRU/MplStud  
    polypeptide O35565 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 6
      cDNA 44
      Primer pair 33
      Other 59

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145479, MGI:3529962
    References
    more
    • Summaries
      All 693
      Developmental Gene Expression 532
      Diseases 2
      Gene Ontology 60
      Phenotypes 171
    • Earliest
      J:31907 Vainio S, et al., Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
    • Latest
      J:346456 Lozovska A, et al., Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Nat Commun. 2024 Mar 20;15(1):2509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory