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Ptpn4 Gene Detail
Summary
  • Symbol
    Ptpn4
  • Name
    protein tyrosine phosphatase, non-receptor type 4
  • Synonyms
    hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), PTPMEG, TEP, TEP/mPTPMEG, testis-enriched phosphatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099792
    NCBI Gene: 19258
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:119580197-119765281 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.39 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099792
 protein coding gene Chr1:119580197-119765343 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016398
 protein coding gene Chr1:122410595-122611769 (-)
A/J MGP_AJ_G0016381
 protein coding gene Chr1:118024165-118211088 (-)
AKR/J MGP_AKRJ_G0016346
 protein coding gene Chr1:121511463-121691758 (-)
BALB/cJ MGP_BALBcJ_G0016341
 protein coding gene Chr1:118288558-118470943 (-)
C3H/HeJ MGP_C3HHeJ_G0016167
 protein coding gene Chr1:121677395-121857124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016802
 protein coding gene Chr1:127094817-127282003 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014515
 protein coding gene Chr1:111685951-111865164 (-)
CAST/EiJ MGP_CASTEiJ_G0015748
 protein coding gene Chr1:120448470-120644705 (-)
CBA/J MGP_CBAJ_G0016140
 protein coding gene Chr1:131471207-131667411 (-)
DBA/2J MGP_DBA2J_G0016246
 protein coding gene Chr1:117044746-117237145 (-)
FVB/NJ MGP_FVBNJ_G0016245
 protein coding gene Chr1:115792992-115983751 (-)
LP/J MGP_LPJ_G0016317
 protein coding gene Chr1:123747946-123945413 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016270
 protein coding gene Chr1:137189573-137424716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016838
 protein coding gene Chr1:121213872-121402897 (-)
PWK/PhJ MGP_PWKPhJ_G0015534
 protein coding gene Chr1:116032966-116211388 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015322
 protein coding gene Chr1:120118193-120303620 (-)
WSB/EiJ MGP_WSBEiJ_G0015810
 protein coding gene Chr1:121096385-121288889 (-)



Homology
more
  • Human Ortholog
    PTPN4, protein tyrosine phosphatase non-receptor type 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN4, protein tyrosine phosphatase non-receptor type 4
  • Synonyms
    MEG, PTPMEG, PTPMEG1
  • Links
    NCBI Gene ID: 5775
    neXtProt AC: NX_P29074
    UniProt: P29074

  • Chr Location
    2q14.2; chr2:119759922-119984899 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    40
  • cDNA Data
    14
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19258 NCBI Gene Model | MGI Sequence Detail 185085 C57BL/6J ±  kb
transcript NM_019933 RefSeq | MGI Sequence Detail 4707 ZRU/MplStud  
polypeptide Q9WU22 UniProt | EBI | MGI Sequence Detail 926 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory