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Clk4 Gene Detail
Summary
  • Symbol
    Clk4
  • Name
    CDC like kinase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098551
    NCBI Gene: 12750
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51153941-51172597 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098551
 protein coding gene Chr11:51152557-51172597 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018266
 protein coding gene Chr11:50483075-50503319 (+)
A/J MGP_AJ_G0018235
 protein coding gene Chr11:48592615-48612174 (+)
AKR/J MGP_AKRJ_G0018205
 protein coding gene Chr11:50118415-50138111 (+)
BALB/cJ MGP_BALBcJ_G0018206
 protein coding gene Chr11:48892818-48913784 (+)
C3H/HeJ MGP_C3HHeJ_G0018017
 protein coding gene Chr11:50152990-50177008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018656
 protein coding gene Chr11:52023091-52042394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016308
 protein coding gene Chr11:46167389-46187219 (+)
CAST/EiJ MGP_CASTEiJ_G0017581
 protein coding gene Chr11:50139618-50158977 (+)
CBA/J MGP_CBAJ_G0017992
 protein coding gene Chr11:54462260-54488311 (+)
DBA/2J MGP_DBA2J_G0018099
 protein coding gene Chr11:48307112-48327276 (+)
FVB/NJ MGP_FVBNJ_G0018094
 protein coding gene Chr11:48003484-48023018 (+)
LP/J MGP_LPJ_G0018175
 protein coding gene Chr11:50912100-50935484 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018117
 protein coding gene Chr11:55876084-55896474 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018699
 protein coding gene Chr11:50211570-50230444 (+)
PWK/PhJ MGP_PWKPhJ_G0017357
 protein coding gene Chr11:48812776-48832719 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017152
 protein coding gene Chr11:49942496-49961795 (+)
WSB/EiJ MGP_WSBEiJ_G0017629
 protein coding gene Chr11:49861084-49880311 (+)



Homology
more
  • Human Ortholog
    CLK4, CDC like kinase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLK4, CDC like kinase 4
  • Links
    NCBI Gene ID: 57396
    neXtProt AC: NX_Q9HAZ1
    UniProt: Q9HAZ1

  • Chr Location
    5q35.3; chr5:178602664-178630615 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in cardiomyocytes exhibit congestive heart failure, enlarged hearts and lungs, cardiac interstitial fibrosis, and abnormal cardiomyocyte sarcomere morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    14
  • cDNA Data
    98
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12750 NCBI Gene Model | MGI Sequence Detail 18657 C57BL/6J ±  kb
    transcript NM_001362538 RefSeq | MGI Sequence Detail 2159 C57BL/6  
    polypeptide O35493 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 99
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144335, MGI:2144675
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:327369 Huang J, et al., CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Nat Commun. 2022 Jul 30;13(1):4433
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory