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Kif11 Gene Detail
Summary
  • Symbol
    Kif11
  • Name
    kinesin family member 11
  • Synonyms
    Eg5, Kifl1, Knsl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098231
    NCBI Gene: 16551
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37364851-37410307 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.27 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098231
 protein coding gene Chr19:37364830-37410311 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025080
 protein coding gene Chr19:36344775-36395959 (+)
A/J MGP_AJ_G0025056
 protein coding gene Chr19:34592273-34638070 (+)
AKR/J MGP_AKRJ_G0025024
 protein coding gene Chr19:35773214-35825486 (+)
BALB/cJ MGP_BALBcJ_G0025054
 protein coding gene Chr19:34678318-34726148 (+)
C3H/HeJ MGP_C3HHeJ_G0024813
 protein coding gene Chr19:35825543-35879785 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025495
 protein coding gene Chr19:37407339-37460753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022913
 protein coding gene Chr19:33957698-34000564 (+)
CAST/EiJ MGP_CASTEiJ_G0024280
 protein coding gene Chr19:35672874-35724256 (+)
CBA/J MGP_CBAJ_G0024790
 protein coding gene Chr19:39138885-39196670 (+)
DBA/2J MGP_DBA2J_G0024922
 protein coding gene Chr19:34446161-34491731 (+)
FVB/NJ MGP_FVBNJ_G0024883
 protein coding gene Chr19:34256948-34302363 (+)
LP/J MGP_LPJ_G0025008
 protein coding gene Chr19:36439134-36493460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024914
 protein coding gene Chr19:38954986-39003508 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025553
 protein coding gene Chr19:35854597-35906157 (+)
PWK/PhJ MGP_PWKPhJ_G0024032
 protein coding gene Chr19:34292149-34342002 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023832
 protein coding gene Chr19:34688844-34744518 (+)
WSB/EiJ MGP_WSBEiJ_G0024347
 protein coding gene Chr19:35943532-35992424 (+)



Homology
more
  • Human Ortholog
    KIF11, kinesin family member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF11, kinesin family member 11
  • Synonyms
    EG5, HKSP, KNSL1, MCLMR, TRIP5
  • Links
    NCBI Gene ID: 3832
    neXtProt AC: NX_P52732
    UniProt: P52732

  • Chr Location
    10q23.33; chr10:92574105-92655395 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KIF11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    122
  • cDNA Data
    190
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000012443 Ensembl Gene Model | MGI Sequence Detail 45457 C57BL/6J ±  kb
    transcript ENSMUST00000012587 Ensembl | MGI Sequence Detail 4819 Not Applicable  
    polypeptide ENSMUSP00000012587 Ensembl | MGI Sequence Detail 1052 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 198
      Genomic 4
      cDNA 192
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1306820
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
    • Latest
      J:334512 He S, et al., Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Nat Commun. 2023 Mar 27;14(1):1715
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory