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Bak1 Gene Detail
Summary
  • Symbol
    Bak1
  • Name
    BCL2-antagonist/killer 1
  • Synonyms
    Bak, N-Bak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097161
    NCBI Gene: 12018
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27238786-27247601 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.65 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097161
 protein coding gene Chr17:27238784-27247983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023415
 protein coding gene Chr17:26256674-26269623 (-)
A/J MGP_AJ_G0023372
 protein coding gene Chr17:25450705-25459868 (-)
AKR/J MGP_AKRJ_G0023338
 protein coding gene Chr17:25590984-25600190 (-)
BALB/cJ MGP_BALBcJ_G0023377
 protein coding gene Chr17:25703866-25713375 (-)
C3H/HeJ MGP_C3HHeJ_G0023138
 protein coding gene Chr17:25969491-25978457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023820
 protein coding gene Chr17:27360683-27371210 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021294
 protein coding gene Chr17:22867450-22876899 (-)
CAST/EiJ MGP_CASTEiJ_G0022639
 protein coding gene Chr17:25894382-25903562 (-)
CBA/J MGP_CBAJ_G0023112
 protein coding gene Chr17:28309594-28320655 (-)
DBA/2J MGP_DBA2J_G0023244
 protein coding gene Chr17:25015016-25023889 (-)
FVB/NJ MGP_FVBNJ_G0023213
 protein coding gene Chr17:24801073-24810231 (-)
LP/J MGP_LPJ_G0023321
 protein coding gene Chr17:26506799-26515939 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023231
 protein coding gene Chr17:27832721-27845407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023861
 protein coding gene Chr17:25959856-25972843 (-)
PWK/PhJ MGP_PWKPhJ_G0022389
 protein coding gene Chr17:23814821-23824543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022207
 protein coding gene Chr17:24002303-24011542 (-)
WSB/EiJ MGP_WSBEiJ_G0022702
 protein coding gene Chr17:25986389-25997942 (-)



Homology
more
  • Human Ortholog
    BAK1, BCL2 antagonist/killer 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAK1, BCL2 antagonist/killer 1
  • Synonyms
    BAK, BAK-LIKE, BCL2L7, CDN1
  • Links
    NCBI Gene ID: 578
    neXtProt AC: NX_Q16611
    UniProt: Q16611

  • Chr Location
    6p21.31; chr6:33572547-33580293 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BAK1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    51 phenotypes from multigenic genotypes
    177 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    82
  • cDNA Data
    56
  • Literature Summary
    28
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12018 NCBI Gene Model | MGI Sequence Detail 8816 C57BL/6J ±  kb
transcript NR_149749 RefSeq | MGI Sequence Detail 2038 C57BL/6  
polypeptide O08734 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    Genomic 1
    cDNA 56
    Primer pair 7
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 305
    Developmental Gene Expression 28
    Gene Ontology 35
    Phenotypes 177
  • Earliest
    J:43660 Chittenden T, et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96
  • Latest
    J:343605 Yusupova M, et al., Apoptotic dysregulation mediates stem cell competition and tissue regeneration. Nat Commun. 2023 Nov 20;14(1):7547
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory