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Etv5 Gene Detail
Summary
  • Symbol
    Etv5
  • Name
    ets variant 5
  • Synonyms
    1110005E01Rik, 8430401F14Rik, erm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096867
    NCBI Gene: 104156
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22200063-22258320 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.30 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096867
 protein coding gene Chr16:22200059-22258469 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022669
 protein coding gene Chr16:19883369-19949035 (-)
A/J MGP_AJ_G0022630
 protein coding gene Chr16:18918485-18976096 (-)
AKR/J MGP_AKRJ_G0022605
 protein coding gene Chr16:19706168-19770603 (-)
BALB/cJ MGP_BALBcJ_G0022635
 protein coding gene Chr16:19112646-19172460 (-)
C3H/HeJ MGP_C3HHeJ_G0022399
 protein coding gene Chr16:19824265-19884892 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023085
 protein coding gene Chr16:20313957-20381744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020603
 protein coding gene Chr16:19612476-19671412 (-)
CAST/EiJ MGP_CASTEiJ_G0021929
 protein coding gene Chr16:19802576-19864498 (-)
CBA/J MGP_CBAJ_G0022371
 protein coding gene Chr16:21166288-21243460 (-)
DBA/2J MGP_DBA2J_G0022503
 protein coding gene Chr16:18891695-18953008 (-)
FVB/NJ MGP_FVBNJ_G0022479
 protein coding gene Chr16:18864535-18921535 (-)
LP/J MGP_LPJ_G0022571
 protein coding gene Chr16:19631358-19695128 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022498
 protein coding gene Chr16:20736567-20798001 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023096
 protein coding gene Chr16:19665024-19730931 (-)
PWK/PhJ MGP_PWKPhJ_G0021669
 protein coding gene Chr16:19139973-19197189 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021499
 protein coding gene Chr16:19438684-19503256 (-)
WSB/EiJ MGP_WSBEiJ_G0021972
 protein coding gene Chr16:19619181-19681346 (-)



Homology
more
  • Human Ortholog
    ETV5, ETS variant transcription factor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ETV5, ETS variant transcription factor 5
  • Synonyms
    ERM
  • Links
    NCBI Gene ID: 2119
    neXtProt AC: NX_P41161
    UniProt: P41161

  • Chr Location
    3q27.2; chr3:186046314-186110318 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display either male infertility, small testes, azoospermia, and failure to maintain spermatogonia or they are prenatally lethal. Preaxial polydactyly has also been observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1435
  • Tissues
    406
  • cDNA Data
    166
  • Literature Summary
    233
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104156 NCBI Gene Model | MGI Sequence Detail 58258 C57BL/6J ±  kb
    transcript NM_001358428 RefSeq | MGI Sequence Detail 4865 C57BL/6  
    polypeptide Q9CXC9 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      cDNA 168
      Primer pair 12
      Other 17

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915818, MGI:1923002
    References
    more
    • Summaries
      All 310
      Developmental Gene Expression 233
      Gene Ontology 8
      Phenotypes 44
    • Earliest
      J:42463 Chotteau-Lelievre A, et al., Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene. 1997 Aug 18;15(8):937-52
    • Latest
      J:338204 Luzzio A, et al., The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. Mamm Genome. 2023 Jun 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory