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Erf Gene Detail
Summary
  • Symbol
    Erf
  • Name
    Ets2 repressor factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109637
    NCBI Gene: 13875
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24941986-24950186 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109637
 protein coding gene Chr7:24941985-24950522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031858
 protein coding gene Chr7:23694977-23703105 (-)
A/J MGP_AJ_G0031837
 protein coding gene Chr7:23088677-23097720 (-)
AKR/J MGP_AKRJ_G0031766
 protein coding gene Chr7:23627728-23637321 (-)
BALB/cJ MGP_BALBcJ_G0031844
 protein coding gene Chr7:23296608-23306684 (-)
C3H/HeJ MGP_C3HHeJ_G0031563
 protein coding gene Chr7:24059556-24067630 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032306
 protein coding gene Chr7:24478183-24487962 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029361
 protein coding gene Chr7:24511044-24519252 (-)
CAST/EiJ MGP_CASTEiJ_G0030903
 protein coding gene Chr7:17527959-17536004 (-)
CBA/J MGP_CBAJ_G0031528
 protein coding gene Chr7:25379008-25390306 (-)
DBA/2J MGP_DBA2J_G0031682
 protein coding gene Chr7:22987971-22996186 (-)
FVB/NJ MGP_FVBNJ_G0031635
 protein coding gene Chr7:22988576-22998126 (-)
LP/J MGP_LPJ_G0031761
 protein coding gene Chr7:23993908-24003819 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031672
 protein coding gene Chr7:25099262-25113442 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032338
 protein coding gene Chr7:23331074-23342047 (-)
PWK/PhJ MGP_PWKPhJ_G0030627
 protein coding gene Chr7:17927092-17935823 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030458
 protein coding gene Chr7:14647437-14659446 (-)
WSB/EiJ MGP_WSBEiJ_G0031006
 protein coding gene Chr7:23507271-23515180 (-)



Homology
more
  • Human Ortholog
    ERF, ETS2 repressor factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERF, ETS2 repressor factor
  • Synonyms
    CHYTS, CRS4, PE2, PE-2
  • Links
    NCBI Gene ID: 2077
    neXtProt AC: NX_P50548
    UniProt: P50548

  • Chr Location
    19q13.2; chr19:42247569-42255128 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ERF associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 5 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality around E10.5, reduced size, brain hypoplasia, defects in extraembryonic tissue formation affecting the chorion, allantois, placental labyrinth and umbilical cord, and increase in apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    113
  • cDNA Data
    35
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040857 Ensembl Gene Model | MGI Sequence Detail 8201 C57BL/6J ±  kb
    transcript ENSMUST00000045847 Ensembl | MGI Sequence Detail 3505 Not Applicable  
    polypeptide ENSMUSP00000041912 Ensembl | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 1
      cDNA 35
      Primer pair 2
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-39636
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 15
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:39443 Liu D, et al., ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. Oncogene. 1997 Mar 27;14(12):1445-51
    • Latest
      J:345015 Tsiomita S, et al., ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment. J Leukoc Biol. 2022 Oct;112(4):641-657
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory