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Bnip2 Gene Detail
Summary
  • Symbol
    Bnip2
  • Name
    BCL2/adenovirus E1B interacting protein 2
  • Synonyms
    5730523P12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:109327
    NCBI Gene: 12175
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69896748-69915599 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109327
 protein coding gene Chr9:69896660-69918941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034994
 protein coding gene Chr9:70019704-70039618 (+)
A/J MGP_AJ_G0034975
 protein coding gene Chr9:67608104-67626988 (+)
AKR/J MGP_AKRJ_G0034904
 protein coding gene Chr9:69211646-69230490 (+)
BALB/cJ MGP_BALBcJ_G0034967
 protein coding gene Chr9:67329990-67349142 (+)
C3H/HeJ MGP_C3HHeJ_G0034676
 protein coding gene Chr9:69715059-69733815 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035486
 protein coding gene Chr9:71895763-71915642 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032397
 protein coding gene Chr9:67162433-67181138 (+)
CAST/EiJ MGP_CASTEiJ_G0033998
 protein coding gene Chr9:69985514-70004227 (+)
CBA/J MGP_CBAJ_G0034649
 protein coding gene Chr9:74405524-74424313 (+)
DBA/2J MGP_DBA2J_G0034808
 protein coding gene Chr9:67352723-67371506 (+)
FVB/NJ MGP_FVBNJ_G0034750
 protein coding gene Chr9:66670342-66689087 (+)
LP/J MGP_LPJ_G0034889
 protein coding gene Chr9:70269807-70288678 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034791
 protein coding gene Chr9:75493394-75512803 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035508
 protein coding gene Chr9:69350238-69369957 (+)
PWK/PhJ MGP_PWKPhJ_G0033702
 protein coding gene Chr9:67582976-67602480 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033535
 protein coding gene Chr9:69656090-69675050 (+)
WSB/EiJ MGP_WSBEiJ_G0034110
 protein coding gene Chr9:69239639-69259700 (+)



Homology
more
  • Human Ortholog
    BNIP2, BCL2 interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BNIP2, BCL2 interacting protein 2
  • Synonyms
    BNIP-2, NIP2
  • Links
    NCBI Gene ID: 663
    neXtProt AC: NX_Q12982
    UniProt: Q12982

  • Chr Location
    15q22.2; chr15:59659146-59689339 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    113
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011958 Ensembl Gene Model | MGI Sequence Detail 18852 C57BL/6J ±  kb
    transcript ENSMUST00000117450 Ensembl | MGI Sequence Detail 1465 Not Applicable  
    polypeptide ENSMUSP00000113466 Ensembl | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000004780 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR022181 Bcl2-/adenovirus E1B 19kDa-interacting protein 2
      IPR001251 CRAL-TRIO lipid binding domain
      IPR036865 CRAL-TRIO lipid binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 115
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-38372, MGI:1923989
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:37511 Boyd JM, et al., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins [see comments] [published erratum appears in Cell 1994 Dec 16;79(6):following 1120]. Cell. 1994 Oct 21;79(2):341-51
    • Latest
      J:329983 Fidalgo MF, et al., Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes. Life Sci Alliance. 2022 Dec;5(12):e202201554
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory