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Bnip3 Gene Detail
Summary
  • Symbol
    Bnip3
  • Name
    BCL2/adenovirus E1B interacting protein 3
  • Synonyms
    Nip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109326
    NCBI Gene: 12176
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:138492565-138511235 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 82.95 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109326
 protein coding gene Chr7:138492565-138511248 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033144
 protein coding gene Chr7:143889765-143905886 (-)
A/J MGP_AJ_G0033126
 protein coding gene Chr7:139843683-139862613 (-)
AKR/J MGP_AKRJ_G0033058
 protein coding gene Chr7:143614127-143632706 (-)
BALB/cJ MGP_BALBcJ_G0033127
 protein coding gene Chr7:139589955-139605191 (-)
C3H/HeJ MGP_C3HHeJ_G0032841
 protein coding gene Chr7:143427140-143444827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033638
 protein coding gene Chr7:149223800-149244576 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030611
 protein coding gene Chr7:140992329-141011280 (-)
CAST/EiJ MGP_CASTEiJ_G0032171
 protein coding gene Chr7:135700716-135721347 (-)
CBA/J MGP_CBAJ_G0032814
 protein coding gene Chr7:154255181-154272776 (-)
DBA/2J MGP_DBA2J_G0032966
 protein coding gene Chr7:137803965-137824647 (-)
FVB/NJ MGP_FVBNJ_G0032919
 protein coding gene Chr7:137684553-137699774 (-)
LP/J MGP_LPJ_G0033060
 protein coding gene Chr7:145440162-145458845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032951
 protein coding gene Chr7:154977337-154996559 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033658
 protein coding gene Chr7:142608909-142628352 (-)
PWK/PhJ MGP_PWKPhJ_G0031877
 protein coding gene Chr7:130976519-130995944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031722
 protein coding gene Chr7:129432223-129454666 (-)
WSB/EiJ MGP_WSBEiJ_G0032282
 protein coding gene Chr7:143510258-143530506 (-)



Homology
more
  • Human Ortholog
    BNIP3, BCL2 interacting protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BNIP3, BCL2 interacting protein 3
  • Synonyms
    HABON, NIP3
  • Links
    NCBI Gene ID: 664
    neXtProt AC: NX_Q12983
    UniProt: Q12983

  • Chr Location
    10q26.3; chr10:131967684-131981967 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased post-ischemic ventricular remodeling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    69
  • cDNA Data
    144
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12176 NCBI Gene Model | MGI Sequence Detail 18671 C57BL/6J ±  kb
    transcript NM_009760 RefSeq | MGI Sequence Detail 1756 C57BL/6  
    polypeptide O55003 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 144
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38371
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 34
      Gene Ontology 15
      Phenotypes 23
    • Earliest
      J:37511 Boyd JM, et al., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins [see comments] [published erratum appears in Cell 1994 Dec 16;79(6):following 1120]. Cell. 1994 Oct 21;79(2):341-51
    • Latest
      J:344735 Lee SI, et al., HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320. Biochem Biophys Res Commun. 2023 Nov 25;691:149320
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory