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Elavl3 Gene Detail
Summary
  • Symbol
    Elavl3
  • Name
    ELAV like RNA binding protein 3
  • Synonyms
    2600009P04Rik, Huc, mHuC
  • Feature Type
    protein coding gene
  • IDs
    MGI:109157
    NCBI Gene: 15571
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21926301-21963319 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 8.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109157
 protein coding gene Chr9:21926301-21963442 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034474
 protein coding gene Chr9:19292218-19338943 (-)
A/J MGP_AJ_G0034452
 protein coding gene Chr9:18919096-18955059 (-)
AKR/J MGP_AKRJ_G0034378
 protein coding gene Chr9:19285293-19321722 (-)
BALB/cJ MGP_BALBcJ_G0034443
 protein coding gene Chr9:18801219-18837944 (-)
C3H/HeJ MGP_C3HHeJ_G0034155
 protein coding gene Chr9:19589122-19629653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034964
 protein coding gene Chr9:20050161-20110259 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031894
 protein coding gene Chr9:18019695-18057100 (-)
CAST/EiJ MGP_CASTEiJ_G0033478
 protein coding gene Chr9:19425260-19464974 (-)
CBA/J MGP_CBAJ_G0034128
 protein coding gene Chr9:20843360-20885692 (-)
DBA/2J MGP_DBA2J_G0034286
 protein coding gene Chr9:18883291-18920408 (-)
FVB/NJ MGP_FVBNJ_G0034229
 protein coding gene Chr9:18433086-18470600 (-)
LP/J MGP_LPJ_G0034372
 protein coding gene Chr9:19443580-19497017 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034273
 protein coding gene Chr9:22398705-22435663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034984
 protein coding gene Chr9:19250836-19290007 (-)
PWK/PhJ MGP_PWKPhJ_G0033183
 protein coding gene Chr9:18889670-18927472 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033017
 protein coding gene Chr9:19295134-19322591 (-)
WSB/EiJ MGP_WSBEiJ_G0033593
 protein coding gene Chr9:18992481-19029544 (-)



Homology
more
  • Human Ortholog
    ELAVL3, ELAV like RNA binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELAVL3, ELAV like RNA binding protein 3
  • Synonyms
    HUC, HUCL, PLE21
  • Links
    NCBI Gene ID: 1995
    neXtProt AC: NX_Q14576
    UniProt: Q14576

  • Chr Location
    19p13.2; chr19:11451326-11481046 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit strain-specific preweaning lethality, abnormal cortical hypersynchronization and non-convulsive electropgraphic seizure. Mice heterozygous for the allele exhibit abnormal brain wave pattern and spike wave discharge.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    70
  • cDNA Data
    15
  • Literature Summary
    136
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003410 Ensembl Gene Model | MGI Sequence Detail 37019 C57BL/6J ±  kb
transcript ENSMUST00000003501 Ensembl | MGI Sequence Detail 5014 Not Applicable  
polypeptide ENSMUSP00000003501 Ensembl | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-38201, MGI:1913822
References
more
  • Summaries
    All 170
    Developmental Gene Expression 136
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:31495 Abe R, et al., Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. DNA Res. 1994;1(4):175-80
  • Latest
    J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory