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Or10a4 Gene Detail
Summary
  • Symbol
    Or10a4
  • Name
    olfactory receptor family 10 subfamily A member 4
  • Synonyms
    GA_x6K02T2PBJ9-9470146-9471093, MOR263-5, Olfr17, P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109148
    NCBI Gene: 18314
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:106696674-106697621 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 56.10 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109148
 protein coding gene Chr7:106692427-106699015 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032789
 protein coding gene Chr7:110454766-110455713 (+)
A/J MGP_AJ_G0032770
 protein coding gene Chr7:107709724-107710671 (+)
AKR/J MGP_AKRJ_G0032702
 protein coding gene Chr7:110416634-110417581 (+)
BALB/cJ MGP_BALBcJ_G0032776
 protein coding gene Chr7:107415881-107416828 (+)
C3H/HeJ MGP_C3HHeJ_G0032485
 protein coding gene Chr7:110434607-110435554 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033281
 protein coding gene Chr7:114987444-114988391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030261
 protein coding gene Chr7:109349831-109350778 (+)
CAST/EiJ MGP_CASTEiJ_G0031816
 protein coding gene Chr7:102015900-102016847 (+)
CBA/J MGP_CBAJ_G0032460
 protein coding gene Chr7:118804517-118805464 (+)
DBA/2J MGP_DBA2J_G0032611
 protein coding gene Chr7:105847062-105848009 (+)
FVB/NJ MGP_FVBNJ_G0032563
 protein coding gene Chr7:105660400-105661347 (+)
LP/J MGP_LPJ_G0032703
 protein coding gene Chr7:112039441-112040388 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032597
 protein coding gene Chr7:120388744-120389691 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033300
 protein coding gene Chr7:109478470-109479417 (+)
PWK/PhJ MGP_PWKPhJ_G0031524
 protein coding gene Chr7:98717950-98718897 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031374
 protein coding gene Chr7:96044964-96045911 (+)
WSB/EiJ MGP_WSBEiJ_G0031931
 protein coding gene Chr7:110183037-110183984 (+)



Homology
more
  • Human Ortholog
    OR10A4, olfactory receptor family 10 subfamily A member 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OR10A4, olfactory receptor family 10 subfamily A member 4
  • Synonyms
    JCG5, OR10A4P
  • Links
    NCBI Gene ID: 283297
    neXtProt AC: NX_Q9H209
    UniProt: Q9H209

  • Chr Location
    11p15.4; chr11:6876625-6877619 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 9 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene possess olfactory neurons whose axons fail to project to the appropriate glomeruli in the olfactopry bulb.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    21
  • cDNA Data
    2
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18314 NCBI Gene Model | MGI Sequence Detail 948 C57BL/6J ±  kb
    transcript NM_020598 RefSeq | MGI Sequence Detail 948 C57BL/6  
    polypeptide NP_065623 RefSeq | MGI Sequence Detail 315 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR000725 Olfactory receptor
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 3
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38192
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 17
      Gene Ontology 3
      Phenotypes 63
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:328678 Tsukahara T, et al., A transcriptional rheostat couples past activity to future sensory responses. Cell. 2021 Dec 22;184(26):6326-6343.e32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory