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Tia1 Gene Detail
Summary
  • Symbol
    Tia1
  • Name
    cytotoxic granule-associated RNA binding protein 1
  • Synonyms
    2310050N03Rik, mTIA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107914
    NCBI Gene: 21841
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86381201-86410387 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.69 cM, cytoband D2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107914
 protein coding gene Chr6:86381001-86410387 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030975
 protein coding gene Chr6:87685450-87717222 (+)
A/J MGP_AJ_G0030941
 protein coding gene Chr6:84303542-84333903 (+)
AKR/J MGP_AKRJ_G0030872
 protein coding gene Chr6:86742612-86778346 (+)
BALB/cJ MGP_BALBcJ_G0030954
 protein coding gene Chr6:84314384-84343672 (+)
C3H/HeJ MGP_C3HHeJ_G0030756
 protein coding gene Chr6:97685377-97714431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031411
 protein coding gene Chr6:90066103-90100604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028595
 protein coding gene Chr6:82479949-82510306 (+)
CAST/EiJ MGP_CASTEiJ_G0030063
 protein coding gene Chr6:86815111-86845518 (+)
CBA/J MGP_CBAJ_G0030638
 protein coding gene Chr6:93606187-93644330 (+)
DBA/2J MGP_DBA2J_G0030794
 protein coding gene Chr6:83621125-83652095 (+)
FVB/NJ MGP_FVBNJ_G0030747
 protein coding gene Chr6:82805769-82834994 (+)
LP/J MGP_LPJ_G0030871
 protein coding gene Chr6:87720168-87756885 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030780
 protein coding gene Chr6:97740620-97772931 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031438
 protein coding gene Chr6:86592367-86621521 (+)
PWK/PhJ MGP_PWKPhJ_G0029778
 protein coding gene Chr6:82564356-82593971 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029606
 protein coding gene Chr6:85427097-85458023 (+)
WSB/EiJ MGP_WSBEiJ_G0030144
 protein coding gene Chr6:87042041-87072599 (+)



Homology
more
  • Human Ortholog
    TIA1, TIA1 cytotoxic granule associated RNA binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIA1, TIA1 cytotoxic granule associated RNA binding protein
  • Synonyms
    ALS26, TIA-1, WDM
  • Links
    NCBI Gene ID: 7072
    neXtProt AC: NX_P31483
    UniProt: P31483

  • Chr Location
    2p13.3; chr2:70209444-70248793 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced postnatal survival and functional abnormalities in the immune system with no gross abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    130
  • cDNA Data
    167
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071337 Ensembl Gene Model | MGI Sequence Detail 29187 C57BL/6J ±  kb
    transcript ENSMUST00000095753 Ensembl | MGI Sequence Detail 4477 Not Applicable  
    polypeptide ENSMUSP00000093425 Ensembl | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 3
      cDNA 173
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-36494, MGI:1889799, MGI:1914358
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 12
      Gene Ontology 16
      Phenotypes 30
    • Earliest
      J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
    • Latest
      J:338248 Osma-Garcia IC, et al., The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis. Cell Mol Immunol. 2023 Jul 20;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory