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Pvr Gene Detail
Summary
  • Symbol
    Pvr
  • Name
    poliovirus receptor
  • Synonyms
    3830421F03Rik, CD155, D7Ertd458e, mE4, necl-5, Taa1, Tage4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107741
    NCBI Gene: 52118
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19637503-19655068 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.95 cM, cytoband A2-B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107741
 protein coding gene Chr7:19637503-19655085 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031801
 protein coding gene Chr7:17959857-17976348 (-)
A/J MGP_AJ_G0031777
 protein coding gene Chr7:17558524-17580877 (-)
AKR/J MGP_AKRJ_G0031703
 protein coding gene Chr7:18051099-18068509 (-)
BALB/cJ MGP_BALBcJ_G0031782
 protein coding gene Chr7:17768040-17782669 (-)
C3H/HeJ MGP_C3HHeJ_G0031504
 protein coding gene Chr7:18315831-18332097 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032248
 protein coding gene Chr7:18850467-18871919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029314
 protein coding gene Chr7:19196512-19214024 (-)
CAST/EiJ MGP_CASTEiJ_G0030847
 protein coding gene Chr7:14775461-14793231 (-)
CBA/J MGP_CBAJ_G0031466
 protein coding gene Chr7:19546851-19565634 (-)
DBA/2J MGP_DBA2J_G0031621
 protein coding gene Chr7:17507379-17524985 (-)
FVB/NJ MGP_FVBNJ_G0031573
 protein coding gene Chr7:17391125-17409721 (-)
LP/J MGP_LPJ_G0031704
 protein coding gene Chr7:18263278-18294878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031609
 protein coding gene Chr7:19356395-19373961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032276
 protein coding gene Chr7:17667451-17689198 (-)
PWK/PhJ MGP_PWKPhJ_G0030571
 protein coding gene Chr7:14616211-14634303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030398
 protein coding gene Chr7:12386096-12404181 (-)
WSB/EiJ MGP_WSBEiJ_G0030947
 protein coding gene Chr7:17890503-17910336 (-)



Homology
more
  • Human Ortholog
    PVR, PVR cell adhesion molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PVR, PVR cell adhesion molecule
  • Synonyms
    CD155, HVED, Necl-5, NECL5, PVS, TAGE4
  • Links
    NCBI Gene ID: 5817
    neXtProt AC: NX_P15151
    UniProt: P15151

  • Chr Location
    19q13.31; chr19:44643798-44666162 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele have a reduced antibody response to oral immunization. Mice homozygous for a different null allele exhibit reduced susceptibility to chemically induced colon cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    67
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52118 NCBI Gene Model | MGI Sequence Detail 17566 C57BL/6J ±  kb
    transcript NM_027514 RefSeq | MGI Sequence Detail 2902 ZRU/MplStud  
    polypeptide NP_081790 RefSeq | MGI Sequence Detail 408 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 69
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36317, MGI:1196266, MGI:1917954
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:34795 Chadeneau C, et al., Isolation and chromosomal location of mE4, a novel murine gene of the immunoglobulin superfamily. Mamm Genome. 1996 Aug;7(8):636-7
    • Latest
      J:336225 Briukhovetska D, et al., T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Immunity. 2023 Jan 10;56(1):143-161.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory