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Kcnj11 Gene Detail
Summary
  • Symbol
    Kcnj11
  • Name
    potassium inwardly rectifying channel, subfamily J, member 11
  • Synonyms
    Kir6.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107501
    NCBI Gene: 16514
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45746545-45750215 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107501
 protein coding gene Chr7:45743377-45750215 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032259
 protein coding gene Chr7:46448114-46449286 (-)
A/J MGP_AJ_G0032238
 protein coding gene Chr7:45502261-45503433 (-)
AKR/J MGP_AKRJ_G0032174
 protein coding gene Chr7:46790246-46791418 (-)
BALB/cJ MGP_BALBcJ_G0032250
 protein coding gene Chr7:45503336-45504508 (-)
C3H/HeJ MGP_C3HHeJ_G0031965
 protein coding gene Chr7:47283600-47284772 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032742
 protein coding gene Chr7:48723962-48725134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029756
 protein coding gene Chr7:48050054-48051226 (-)
CAST/EiJ MGP_CASTEiJ_G0031293
 protein coding gene Chr7:38714639-38715811 (-)
CBA/J MGP_CBAJ_G0031930
 protein coding gene Chr7:50350272-50351444 (-)
DBA/2J MGP_DBA2J_G0032087
 protein coding gene Chr7:45193497-45194669 (-)
FVB/NJ MGP_FVBNJ_G0032039
 protein coding gene Chr7:44973013-44974185 (-)
LP/J MGP_LPJ_G0032166
 protein coding gene Chr7:47151373-47152545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032076
 protein coding gene Chr7:48999752-49000924 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032757
 protein coding gene Chr7:45995841-45997013 (-)
PWK/PhJ MGP_PWKPhJ_G0031016
 protein coding gene Chr7:38559065-38560237 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030854
 protein coding gene Chr7:34019914-34021086 (-)
WSB/EiJ MGP_WSBEiJ_G0031411
 protein coding gene Chr7:46489397-46490569 (-)



Homology
more
  • Human Ortholog
    KCNJ11, potassium inwardly rectifying channel subfamily J member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ11, potassium inwardly rectifying channel subfamily J member 11
  • Synonyms
    BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, PNDM2, TNDM3
  • Links
    NCBI Gene ID: 3767
    neXtProt AC: NX_Q14654
    UniProt: Q14654

  • Chr Location
    11p15.1; chr11:17365172-17389346 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kcnj11 mouse models; 6 with human KCNJ11 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 7 alleles in 12 genetic backgrounds
    5 phenotypes from multigenic genotypes
    1 images
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired insulin secretion, mild glucose intolerance, reduced glucagon secretion in response to hypoglycemia, hypoxia-induced seizure susceptibility, and stress-induced arrhythmia and sudden death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    29
  • cDNA Data
    6
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16514 NCBI Gene Model | MGI Sequence Detail 3671 C57BL/6J ±  kb
    transcript NM_010602 RefSeq | MGI Sequence Detail 3671 ZRU/MplStud  
    polypeptide Q61743 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 3
      cDNA 6
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36069, MGI:2142042, MGI:2142236
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 22
      Phenotypes 122
    • Earliest
      J:30315 Sakura H, et al., Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett. 1995 Dec 27;377(3):338-44
    • Latest
      J:342574 Shyr ZA, et al., SGLT2 inhibitors therapy protects glucotoxicity-induced beta-cell failure in a mouse model of human KATP-induced diabetes through mitigation of oxidative and ER stress. PLoS One. 2022;17(2):e0258054
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory