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Elavl4 Gene Detail
Summary
  • Symbol
    Elavl4
  • Name
    ELAV like RNA binding protein 4
  • Synonyms
    Hud
  • Feature Type
    protein coding gene
  • IDs
    MGI:107427
    NCBI Gene: 15572
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:110060919-110209106 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 51.42 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1040 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107427
 protein coding gene Chr4:110060919-110209145 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028576
 protein coding gene Chr4:110997102-111149165 (-)
A/J MGP_AJ_G0028539
 protein coding gene Chr4:107001899-107147316 (-)
AKR/J MGP_AKRJ_G0028486
 protein coding gene Chr4:109686055-109836888 (-)
BALB/cJ MGP_BALBcJ_G0028558
 protein coding gene Chr4:107214829-107357111 (-)
C3H/HeJ MGP_C3HHeJ_G0028272
 protein coding gene Chr4:110422888-110576990 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028998
 protein coding gene Chr4:114988631-115145269 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026289
 protein coding gene Chr4:102288809-102432191 (-)
CAST/EiJ MGP_CASTEiJ_G0027708
 protein coding gene Chr4:108288003-108435596 (-)
CBA/J MGP_CBAJ_G0028241
 protein coding gene Chr4:118772841-118925397 (-)
DBA/2J MGP_DBA2J_G0028389
 protein coding gene Chr4:106625570-106779321 (-)
FVB/NJ MGP_FVBNJ_G0028357
 protein coding gene Chr4:105488148-105629016 (-)
LP/J MGP_LPJ_G0028490
 protein coding gene Chr4:111270968-111425252 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028383
 protein coding gene Chr4:123981090-124149536 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029034
 protein coding gene Chr4:109911926-110068417 (-)
PWK/PhJ MGP_PWKPhJ_G0027434
 protein coding gene Chr4:104912930-105059414 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027258
 protein coding gene Chr4:107323628-107468251 (-)
WSB/EiJ MGP_WSBEiJ_G0027789
 protein coding gene Chr4:110103873-110250843 (-)



Homology
more
  • Human Ortholog
    ELAVL4, ELAV like RNA binding protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELAVL4, ELAV like RNA binding protein 4
  • Synonyms
    HUD, PNEM
  • Links
    NCBI Gene ID: 1996
    neXtProt AC: NX_P26378
    UniProt: P26378

  • Chr Location
    1p33-p32.3; chr1:50024029-50203772 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased neural progenitor self-renewal and impaired neuronal differentiation, partial penetrance of hind limb clasping, and impaired coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    114
  • cDNA Data
    52
  • Literature Summary
    153
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028546 Ensembl Gene Model | MGI Sequence Detail 148188 C57BL/6J ±  kb
    transcript ENSMUST00000106597 Ensembl | MGI Sequence Detail 4149 Not Applicable  
    polypeptide ENSMUSP00000102207 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 6
      cDNA 53
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35898
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 153
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:31495 Abe R, et al., Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. DNA Res. 1994;1(4):175-80
    • Latest
      J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory