About   Help   FAQ
Il17a Gene Detail
Summary
  • Symbol
    Il17a
  • Name
    interleukin 17A
  • Synonyms
    Ctla8, Ctla-8, Il17, IL-17A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107364
    NCBI Gene: 16171
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:20801129-20804720 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 6.45 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107364
 protein coding gene Chr1:20801129-20804720 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015870
 protein coding gene Chr1:18352108-18355696 (+)
A/J MGP_AJ_G0015851
 protein coding gene Chr1:18130858-18134448 (+)
AKR/J MGP_AKRJ_G0015810
 protein coding gene Chr1:18157380-18160970 (+)
BALB/cJ MGP_BALBcJ_G0015807
 protein coding gene Chr1:17830231-17833821 (+)
C3H/HeJ MGP_C3HHeJ_G0015641
 protein coding gene Chr1:18189876-18193466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016261
 protein coding gene Chr1:19213761-19217351 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013982
 protein coding gene Chr1:16273365-16276959 (+)
CAST/EiJ MGP_CASTEiJ_G0015222
 protein coding gene Chr1:18284208-18287803 (+)
CBA/J MGP_CBAJ_G0015614
 protein coding gene Chr1:19655406-19658996 (+)
DBA/2J MGP_DBA2J_G0015713
 protein coding gene Chr1:17630104-17633694 (+)
FVB/NJ MGP_FVBNJ_G0015718
 protein coding gene Chr1:17394669-17398259 (+)
LP/J MGP_LPJ_G0015785
 protein coding gene Chr1:18575590-18579261 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015736
 protein coding gene Chr1:20611818-20616334 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016308
 protein coding gene Chr1:18142189-18145779 (+)
PWK/PhJ MGP_PWKPhJ_G0015006
 protein coding gene Chr1:17373193-17376790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014787
 protein coding gene Chr1:18234932-18238540 (+)
WSB/EiJ MGP_WSBEiJ_G0015285
 protein coding gene Chr1:18079314-18082904 (+)



Homology
more
  • Human Ortholog
    IL17A, interleukin 17A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17A, interleukin 17A
  • Synonyms
    CTLA8, CTLA-8, IL17, IL-17, IL-17A, ILA17
  • Links
    NCBI Gene ID: 3605
    neXtProt AC: NX_Q16552
    UniProt: Q16552

  • Chr Location
    6p12.2; chr6:52186375-52190638 (+)  GRCh38
Human Diseases
more
  • Diseases
    12 with human IL17A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 7 genetic backgrounds
    44 phenotypes from multigenic genotypes
    1 images
    541 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced contact, delayed-type and airway hypersensitivity responses and impaired T-dependent antibody production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16171 NCBI Gene Model | MGI Sequence Detail 3592 C57BL/6J ±  kb
    transcript NM_010552 RefSeq | MGI Sequence Detail 1171 C57BL/6  
    polypeptide Q62386 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-2228, MGD-MRK-2238, MGD-MRK-35831
    References
    more
    • Summaries
      All 1016
      Developmental Gene Expression 4
      Gene Ontology 24
      Phenotypes 541
    • Earliest
      J:12608 Rouvier E, et al., CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol. 1993 Jun 15;150(12):5445-56
    • Latest
      J:344532 Taylor BE, et al., IL-17A Enhances Retinal Neovascularization. Int J Mol Sci. 2023 Jan 16;24(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory