About   Help   FAQ
Fosl1 Gene Detail
Summary
  • Symbol
    Fosl1
  • Name
    fos-like antigen 1
  • Synonyms
    fra-1, Fra1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107179
    NCBI Gene: 14283
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5497726-5505966 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.33 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107179
 protein coding gene Chr19:5497575-5505974 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024706
 protein coding gene Chr19:2416940-2425183 (+)
A/J MGP_AJ_G0024672
 protein coding gene Chr19:2282360-2290591 (+)
AKR/J MGP_AKRJ_G0024645
 protein coding gene Chr19:2340268-2348497 (+)
BALB/cJ MGP_BALBcJ_G0024672
 protein coding gene Chr19:2274939-2284334 (+)
C3H/HeJ MGP_C3HHeJ_G0024440
 protein coding gene Chr19:2349834-2358065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025119
 protein coding gene Chr19:2470854-2480774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022549
 protein coding gene Chr19:2184207-2192725 (+)
CAST/EiJ MGP_CASTEiJ_G0023912
 protein coding gene Chr19:2377209-2385457 (+)
CBA/J MGP_CBAJ_G0024412
 protein coding gene Chr19:2581386-2590164 (+)
DBA/2J MGP_DBA2J_G0024539
 protein coding gene Chr19:2261356-2269969 (+)
FVB/NJ MGP_FVBNJ_G0024506
 protein coding gene Chr19:2268517-2276750 (+)
LP/J MGP_LPJ_G0024625
 protein coding gene Chr19:2396377-2404647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024536
 protein coding gene Chr19:2435624-2444836 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025167
 protein coding gene Chr19:2357062-2366320 (+)
PWK/PhJ MGP_PWKPhJ_G0023658
 protein coding gene Chr19:2298450-2306871 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023463
 protein coding gene Chr19:2340034-2348452 (+)
WSB/EiJ MGP_WSBEiJ_G0023974
 protein coding gene Chr19:2368973-2377238 (+)



Homology
more
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
  • Synonyms
    FRA, fra-1, FRA1
  • Links
    NCBI Gene ID: 8061
    neXtProt AC: NX_P15407
    UniProt: P15407

  • Chr Location
    11q13.1; chr11:65892049-65900573 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FOSL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 5 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    130
  • cDNA Data
    24
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14283 NCBI Gene Model | MGI Sequence Detail 8241 C57BL/6J ±  kb
    transcript NM_010235 RefSeq | MGI Sequence Detail 1705 ZRU/MplStud  
    polypeptide P48755 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 1
      cDNA 25
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35640, MGI:2147739
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:23980 Carrasco D, et al., Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development. Oncogene. 1995 Mar 16;10(6):1069-79
    • Latest
      J:335233 Astrof S, et al., Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol. 2023 Apr 14;499:10-21
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory