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Melk Gene Detail
Summary
  • Symbol
    Melk
  • Name
    maternal embryonic leucine zipper kinase
  • Synonyms
    mKIAA0175, MPK38
  • Feature Type
    protein coding gene
  • IDs
    MGI:106924
    NCBI Gene: 17279
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:44300876-44364301 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106924
 protein coding gene Chr4:44300876-44364675 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028234
 protein coding gene Chr4:42471363-42532311 (+)
A/J MGP_AJ_G0028191
 protein coding gene Chr4:40961660-41023534 (+)
AKR/J MGP_AKRJ_G0028143
 protein coding gene Chr4:41917693-41975903 (+)
BALB/cJ MGP_BALBcJ_G0028211
 protein coding gene Chr4:41046984-41110145 (+)
C3H/HeJ MGP_C3HHeJ_G0027933
 protein coding gene Chr4:42536794-42597067 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028652
 protein coding gene Chr4:44088949-44153768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025962
 protein coding gene Chr4:38379188-38434573 (+)
CAST/EiJ MGP_CASTEiJ_G0027372
 protein coding gene Chr4:42052781-42115438 (+)
CBA/J MGP_CBAJ_G0027899
 protein coding gene Chr4:45455771-45526533 (+)
DBA/2J MGP_DBA2J_G0028048
 protein coding gene Chr4:40857635-40919788 (+)
FVB/NJ MGP_FVBNJ_G0028015
 protein coding gene Chr4:40090756-40147954 (+)
LP/J MGP_LPJ_G0028147
 protein coding gene Chr4:42543874-42603757 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028039
 protein coding gene Chr4:48639005-48705334 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028688
 protein coding gene Chr4:42131402-42197179 (+)
PWK/PhJ MGP_PWKPhJ_G0027096
 protein coding gene Chr4:40906232-40965551 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026925
 protein coding gene Chr4:41654101-41715476 (+)
WSB/EiJ MGP_WSBEiJ_G0027450
 protein coding gene Chr4:42008433-42068576 (+)



Homology
more
  • Human Ortholog
    MELK, maternal embryonic leucine zipper kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MELK, maternal embryonic leucine zipper kinase
  • Synonyms
    HPK38
  • Links
    NCBI Gene ID: 9833
    neXtProt AC: NX_Q14680
    UniProt: Q14680

  • Chr Location
    9p13.2; chr9:36572862-36677683 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an allele that produces a kinase-dead protein exhibit altered pancreatic regeneration following injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1189
  • Tissues
    190
  • cDNA Data
    101
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17279 NCBI Gene Model | MGI Sequence Detail 63426 C57BL/6J ±  kb
    transcript NM_010790 RefSeq | MGI Sequence Detail 2501 ZRU/MplStud  
    polypeptide Q61846 UniProt | EBI | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 103
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35385, MGI:2140251
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory