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Adra1d Gene Detail
Summary
  • Symbol
    Adra1d
  • Name
    adrenergic receptor, alpha 1d
  • Synonyms
    Adra1, Adra-1, Adra1a, alpha1D-AR, Gpcr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:106673
    NCBI Gene: 11550
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131387770-131404203 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106673
 protein coding gene Chr2:131387277-131404417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026532
 protein coding gene Chr2:135087660-135104132 (-)
A/J MGP_AJ_G0026496
 protein coding gene Chr2:129595853-129612279 (-)
AKR/J MGP_AKRJ_G0026471
 protein coding gene Chr2:133329442-133345892 (-)
BALB/cJ MGP_BALBcJ_G0026508
 protein coding gene Chr2:129984861-130001298 (-)
C3H/HeJ MGP_C3HHeJ_G0026251
 protein coding gene Chr2:133792647-133809109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026953
 protein coding gene Chr2:139224563-139241004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024330
 protein coding gene Chr2:124332475-124348695 (-)
CAST/EiJ MGP_CASTEiJ_G0025712
 protein coding gene Chr2:134064192-134080513 (-)
CBA/J MGP_CBAJ_G0026231
 protein coding gene Chr2:144417967-144434435 (-)
DBA/2J MGP_DBA2J_G0026365
 protein coding gene Chr2:128986705-129003036 (-)
FVB/NJ MGP_FVBNJ_G0026329
 protein coding gene Chr2:127613137-127630575 (-)
LP/J MGP_LPJ_G0026470
 protein coding gene Chr2:135308469-135324924 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026349
 protein coding gene Chr2:148231241-148247649 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027008
 protein coding gene Chr2:133312783-133329251 (-)
PWK/PhJ MGP_PWKPhJ_G0025448
 protein coding gene Chr2:128569147-128585544 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025250
 protein coding gene Chr2:132470174-132486660 (-)
WSB/EiJ MGP_WSBEiJ_G0025786
 protein coding gene Chr2:134218944-134235571 (-)



Homology
more
  • Human Ortholog
    ADRA1D, adrenoceptor alpha 1D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRA1D, adrenoceptor alpha 1D
  • Synonyms
    ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
  • Links
    NCBI Gene ID: 146
    neXtProt AC: NX_P25100
    UniProt: P25100

  • Chr Location
    20p13; chr20:4220630-4249287 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hypotension or reduced rearing behavior in a novel environment, decreased wheel-running activity during the night, and reduced hyperlocomotion after amphetamine administration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    12
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027335 Ensembl Gene Model | MGI Sequence Detail 16434 C57BL/6J ±  kb
    transcript ENSMUST00000103184 Ensembl | MGI Sequence Detail 1899 Not Applicable  
    polypeptide ENSMUSP00000099473 Ensembl | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 9
      Primer pair 2
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1134, MGD-MRK-1139, MGD-MRK-16339, MGD-MRK-28037, MGD-MRK-35132, MGI:104746, MGI:99561
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345649 Sandroni PB, et al., The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart. J Mol Cell Cardiol. 2024 Feb;187:101-117
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory