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Dusp8 Gene Detail
Summary
  • Symbol
    Dusp8
  • Name
    dual specificity phosphatase 8
  • Synonyms
    5530400B01Rik, Nttp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106626
    NCBI Gene: 18218
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141633227-141649580 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.59 cM, cytoband F5
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106626
 protein coding gene Chr7:141633224-141649799 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033245
 protein coding gene Chr7:147286089-147302424 (-)
A/J MGP_AJ_G0033226
 protein coding gene Chr7:143058589-143074942 (-)
AKR/J MGP_AKRJ_G0033160
 protein coding gene Chr7:147049985-147066354 (-)
BALB/cJ MGP_BALBcJ_G0033228
 protein coding gene Chr7:142794670-142811502 (-)
C3H/HeJ MGP_C3HHeJ_G0032942
 protein coding gene Chr7:146774179-146790520 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033740
 protein coding gene Chr7:152645121-152661480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030713
 protein coding gene Chr7:144244371-144260543 (-)
CAST/EiJ MGP_CASTEiJ_G0032273
 protein coding gene Chr7:139099877-139116209 (-)
CBA/J MGP_CBAJ_G0032915
 protein coding gene Chr7:157827125-157843452 (-)
DBA/2J MGP_DBA2J_G0033067
 protein coding gene Chr7:140997771-141014122 (-)
FVB/NJ MGP_FVBNJ_G0033019
 protein coding gene Chr7:140916256-140932657 (-)
LP/J MGP_LPJ_G0033162
 protein coding gene Chr7:148781833-148798182 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033053
 protein coding gene Chr7:158446715-158463219 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033758
 protein coding gene Chr7:145994539-146010873 (-)
PWK/PhJ MGP_PWKPhJ_G0031977
 protein coding gene Chr7:134289811-134306207 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031823
 protein coding gene Chr7:132808493-132825138 (-)
WSB/EiJ MGP_WSBEiJ_G0032383
 protein coding gene Chr7:146966690-146983270 (-)



Homology
more
  • Human Ortholog
    DUSP8, dual specificity phosphatase 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP8, dual specificity phosphatase 8
  • Synonyms
    C11orf81, HB5, HVH-5, HVH8
  • Links
    NCBI Gene ID: 1850
    neXtProt AC: NX_Q13202
    UniProt: Q13202

  • Chr Location
    11p15.5; chr11:1554051-1572848 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered myocardial fiber morphology, mildly increased cardiac muscle contractility at baseline, and decreased response of heart to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    43
  • cDNA Data
    52
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037887 Ensembl Gene Model | MGI Sequence Detail 16354 C57BL/6J ±  kb
    transcript ENSMUST00000039926 Ensembl | MGI Sequence Detail 4804 Not Applicable  
    polypeptide ENSMUSP00000049414 Ensembl | MGI Sequence Detail 663 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006758 dual specificity protein phosphatase 8
      (term hierarchy)
    • EC
      3.1.3.16, 3.1.3.48
    • InterPro Domains
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR048035 Dual specificity protein phosphatase 8, dual specificity phosphatase domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR029021 Protein-tyrosine phosphatase-like
      IPR001763 Rhodanese-like domain
      IPR036873 Rhodanese-like domain superfamily
      IPR000387 Tyrosine-specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 53
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35083, MGI:1918684, MGI:2142006
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:234006 Martell KJ, et al., hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. J Neurochem. 1995 Oct;65(4):1823-33
    • Latest
      J:342156 Chuang HC, et al., DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. J Clin Invest. 2023 Nov 1;133(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory