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Ilrun Gene Detail
Summary
  • Symbol
    Ilrun
  • Name
    inflammation and lipid regulator with UBA-like and NBR1-like domains
  • Synonyms
    D17Wsu92e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106281
    NCBI Gene: 224647
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27970206-28039516 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.59 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106281
protein coding gene Chr17:27970206-28039622 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023427
protein coding gene Chr17:27079559-27149178 (-)
A/J MGP_AJ_G0023385
protein coding gene Chr17:26215729-26285068 (-)
AKR/J MGP_AKRJ_G0023350
protein coding gene Chr17:26387833-26464275 (-)
BALB/cJ MGP_BALBcJ_G0023390
protein coding gene Chr17:26487668-26557446 (-)
C3H/HeJ MGP_C3HHeJ_G0023151
protein coding gene Chr17:26759056-26835619 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023832
protein coding gene Chr17:28205353-28278591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021307
protein coding gene Chr17:23602447-23670449 (-)
CAST/EiJ MGP_CASTEiJ_G0022652
protein coding gene Chr17:26728716-26803679 (-)
CBA/J MGP_CBAJ_G0023125
protein coding gene Chr17:29181544-29259797 (-)
DBA/2J MGP_DBA2J_G0023256
protein coding gene Chr17:25778696-25847806 (-)
FVB/NJ MGP_FVBNJ_G0023226
protein coding gene Chr17:25569607-25642381 (-)
LP/J MGP_LPJ_G0023334
protein coding gene Chr17:27345607-27421351 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023244
protein coding gene Chr17:28663255-28737395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023874
protein coding gene Chr17:26798173-26879193 (-)
PWK/PhJ MGP_PWKPhJ_G0022402
protein coding gene Chr17:24574004-24644365 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022220
protein coding gene Chr17:24807474-24888404 (-)
WSB/EiJ MGP_WSBEiJ_G0022714
protein coding gene Chr17:26783458-26862555 (-)



Homology
more
  • Human Ortholog
    ILRUN, inflammation and lipid regulator with UBA-like and NBR1-like domains
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ILRUN, inflammation and lipid regulator with UBA-like and NBR1-like domains
  • Synonyms
    C6orf106, dJ391O22.4, FP852
  • Links
    NCBI Gene ID: 64771
    neXtProt AC: NX_Q9H6K1
    UniProt: Q9H6K1

  • Chr Location
    6p21.31; chr6:34587288-34696859 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased plasma HDL cholesterol levels due to reduced liver lipoprotein production, decreased circulating LDL cholesterol and phospholipid levels, reduced VLDL-triglyceride secretion, and impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224647 NCBI Gene Model | MGI Sequence Detail 69311 C57BL/6J ±  kb
    transcript NM_001033279 RefSeq | MGI Sequence Detail 3812 ZRU/MplStud  
    polypeptide Q3TT38 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      Genomic 1
      cDNA 206
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33973, MGI:2146985, MGI:2147136
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:338376 Tribolet L, et al., Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice. Immunobiology. 2023 May;228(3):152380

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory