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Ccr2 Gene Detail
Summary
  • Symbol
    Ccr2
  • Name
    C-C motif chemokine receptor 2
  • Synonyms
    CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, Cmkbr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106185
    NCBI Gene: 12772
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123901987-123913594 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 75.05 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106185
 protein coding gene Chr9:123901954-123913594 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035492
 protein coding gene Chr9:127230855-127242413 (+)
A/J MGP_AJ_G0035470
 protein coding gene Chr9:122316291-122327877 (+)
AKR/J MGP_AKRJ_G0035403
 protein coding gene Chr9:125584748-125596355 (+)
BALB/cJ MGP_BALBcJ_G0035466
 protein coding gene Chr9:122248033-122259628 (+)
C3H/HeJ MGP_C3HHeJ_G0035173
 protein coding gene Chr9:126036319-126047918 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035989
 protein coding gene Chr9:130675861-130687444 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032871
 protein coding gene Chr9:119749974-119761521 (+)
CAST/EiJ MGP_CASTEiJ_G0034478
 protein coding gene Chr9:126040216-126051826 (+)
CBA/J MGP_CBAJ_G0035141
 protein coding gene Chr9:135493184-135504748 (+)
DBA/2J MGP_DBA2J_G0035300
 protein coding gene Chr9:121807508-121819084 (+)
FVB/NJ MGP_FVBNJ_G0035247
 protein coding gene Chr9:120652240-120663783 (+)
LP/J MGP_LPJ_G0035379
 protein coding gene Chr9:127606982-127620605 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035288
 protein coding gene Chr9:136310218-136321753 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036008
 protein coding gene Chr9:126078461-126090051 (+)
PWK/PhJ MGP_PWKPhJ_G0034182
 protein coding gene Chr9:122205047-122216683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034020
 protein coding gene Chr9:126108525-126120123 (+)
WSB/EiJ MGP_WSBEiJ_G0034598
 protein coding gene Chr9:125858115-125869678 (+)



Homology
more
  • Human Ortholog
    CCR2, C-C motif chemokine receptor 2
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCR2, C-C motif chemokine receptor 2
  • Synonyms
    CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, PCLUD
  • Links
    NCBI Gene ID: 729230
    neXtProt AC: NX_P41597
    UniProt: P41597

  • Chr Location
    3p21.31; chr3:46353864-46360940 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ccr2 mouse models; 18 with human CCR2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
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IDs
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IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    102 phenotypes from 9 alleles in 16 genetic backgrounds
    33 phenotypes from multigenic genotypes
    1 images
    798 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in leukocyte physiology that result in altered response to myocardial infarction and increased susceptibility to bacterial infection and colitis. Mice may also exhibit retinal degeneration and alcohol aversion depending on the knock-out allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    50
  • cDNA Data
    30
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049103 Ensembl Gene Model | MGI Sequence Detail 11608 C57BL/6J ±  kb
    transcript ENSMUST00000055918 Ensembl | MGI Sequence Detail 2999 Not Applicable  
    polypeptide ENSMUSP00000049909 Ensembl | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 2
      cDNA 31
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33876
    References
    more
    • Summaries
      All 950
      Developmental Gene Expression 14
      Diseases 3
      Gene Ontology 31
      Phenotypes 798
    • Earliest
      J:28836 Kozak CA, et al., Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9. Genomics. 1995 Sep 1;29(1):294-6
    • Latest
      J:346027 Orchanian SB, et al., Deficiency in astrocyte CCL2 production reduces neuroimmune control of Toxoplasma gondii infection. PLoS Pathog. 2024 Jan;20(1):e1011710
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory