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Shc3 Gene Detail
Summary
  • Symbol
    Shc3
  • Name
    src homology 2 domain-containing transforming protein C3
  • Synonyms
    N-Shc, Rai, ShcC
  • Feature Type
    protein coding gene
  • IDs
    MGI:106179
    NCBI Gene: 20418
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51585077-51723523 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 26.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106179
 protein coding gene Chr13:51577422-51724909 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020550
 protein coding gene Chr13:50627533-50780221 (-)
A/J MGP_AJ_G0020504
 protein coding gene Chr13:48843957-48980024 (-)
AKR/J MGP_AKRJ_G0020482
 protein coding gene Chr13:50238390-50378541 (-)
BALB/cJ MGP_BALBcJ_G0020500
 protein coding gene Chr13:49040103-49174469 (-)
C3H/HeJ MGP_C3HHeJ_G0020300
 protein coding gene Chr13:50067801-50214664 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020934
 protein coding gene Chr13:52197122-52348624 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018516
 protein coding gene Chr13:46647452-46786810 (-)
CAST/EiJ MGP_CASTEiJ_G0019813
 protein coding gene Chr13:50027599-50178893 (-)
CBA/J MGP_CBAJ_G0020259
 protein coding gene Chr13:54232263-54391288 (-)
DBA/2J MGP_DBA2J_G0020382
 protein coding gene Chr13:48414069-48554797 (-)
FVB/NJ MGP_FVBNJ_G0020361
 protein coding gene Chr13:47847869-47981646 (-)
LP/J MGP_LPJ_G0020458
 protein coding gene Chr13:50900093-51048255 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020390
 protein coding gene Chr13:53823515-53972697 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020977
 protein coding gene Chr13:49796960-49947349 (-)
PWK/PhJ MGP_PWKPhJ_G0019570
 protein coding gene Chr13:48335765-48476412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019397
 protein coding gene Chr13:48696097-48841289 (-)
WSB/EiJ MGP_WSBEiJ_G0019875
 protein coding gene Chr13:50095759-50248118 (-)



Homology
more
  • Human Ortholog
    SHC3, SHC adaptor protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHC3, SHC adaptor protein 3
  • Synonyms
    N-Shc, NSHC, RAI, SHCC
  • Links
    NCBI Gene ID: 53358
    neXtProt AC: NX_Q92529
    UniProt: Q92529

  • Chr Location
    9q22.1; chr9:89005771-89178818 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    17 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    79
  • cDNA Data
    13
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021448 Ensembl Gene Model | MGI Sequence Detail 138447 C57BL/6J ±  kb
transcript ENSMUST00000239056 Ensembl | MGI Sequence Detail 3940 Not Applicable  
polypeptide ENSMUSP00000158865 Ensembl | MGI Sequence Detail 594 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33869
References
more
  • Summaries
    All 52
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory