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Sstr4 Gene Detail
Summary
  • Symbol
    Sstr4
  • Name
    somatostatin receptor 4
  • Synonyms
    Smstr4, sst4
  • Feature Type
    protein coding gene
  • IDs
    MGI:105372
    NCBI Gene: 20608
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:148237297-148238684 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 73.44 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105372
 protein coding gene Chr2:148237264-148238687 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026606
 protein coding gene Chr2:152736810-152738233 (+)
A/J MGP_AJ_G0026570
 protein coding gene Chr2:146527372-146528795 (+)
AKR/J MGP_AKRJ_G0026544
 protein coding gene Chr2:150758758-150760181 (+)
BALB/cJ MGP_BALBcJ_G0026582
 protein coding gene Chr2:146946425-146947848 (+)
C3H/HeJ MGP_C3HHeJ_G0026325
 protein coding gene Chr2:151258511-151259934 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027027
 protein coding gene Chr2:157182843-157184266 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024405
 protein coding gene Chr2:140535296-140536719 (+)
CAST/EiJ MGP_CASTEiJ_G0025786
 protein coding gene Chr2:151645369-151646792 (+)
CBA/J MGP_CBAJ_G0026305
 protein coding gene Chr2:162949326-162950749 (+)
DBA/2J MGP_DBA2J_G0026439
 protein coding gene Chr2:145796991-145798414 (+)
FVB/NJ MGP_FVBNJ_G0026403
 protein coding gene Chr2:144293330-144294753 (+)
LP/J MGP_LPJ_G0026543
 protein coding gene Chr2:152854721-152856144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026423
 protein coding gene Chr2:167021240-167022663 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027082
 protein coding gene Chr2:150765155-150766578 (+)
PWK/PhJ MGP_PWKPhJ_G0025522
 protein coding gene Chr2:145479559-145480982 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025323
 protein coding gene Chr2:149734825-149736243 (+)
WSB/EiJ MGP_WSBEiJ_G0025860
 protein coding gene Chr2:151716274-151717697 (+)



Homology
more
  • Human Ortholog
    SSTR4, somatostatin receptor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSTR4, somatostatin receptor 4
  • Synonyms
    SS4R, SS-4-R, SS4-R, SST4
  • Links
    NCBI Gene ID: 6754
    neXtProt AC: NX_P31391
    UniProt: P31391

  • Chr Location
    20p11.21; chr20:23035312-23039237 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    79
  • cDNA Data
    7
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20608 NCBI Gene Model | MGI Sequence Detail 1388 C57BL/6J ±  kb
    transcript NM_009219 RefSeq | MGI Sequence Detail 1388 ZRU/MplStud  
    polypeptide P49660 UniProt | EBI | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 4
      cDNA 7
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33041
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:322198 Nemes B, et al., Human Somatostatin SST4 Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization. Int J Mol Sci. 2021 Apr 4;22(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory