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Actg2 Gene Detail
Summary
  • Symbol
    Actg2
  • Name
    actin, gamma 2, smooth muscle, enteric
  • Synonyms
    Act4, Act-4, Acta3, SMGA
  • Feature Type
    protein coding gene
  • IDs
    MGI:104589
    NCBI Gene: 11468
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83489891-83513233 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104589
 protein coding gene Chr6:83489887-83513247 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030933
 protein coding gene Chr6:84518471-84542755 (-)
A/J MGP_AJ_G0030902
 protein coding gene Chr6:81310473-81333331 (-)
AKR/J MGP_AKRJ_G0030830
 protein coding gene Chr6:83661712-83685218 (-)
BALB/cJ MGP_BALBcJ_G0030912
 protein coding gene Chr6:81333194-81355785 (-)
C3H/HeJ MGP_C3HHeJ_G0030798
 protein coding gene Chr6:100704152-100728223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031372
 protein coding gene Chr6:86845432-86870785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028558
 protein coding gene Chr6:79662395-79684898 (-)
CAST/EiJ MGP_CASTEiJ_G0030021
 protein coding gene Chr6:83681512-83704427 (-)
CBA/J MGP_CBAJ_G0030599
 protein coding gene Chr6:90250646-90276365 (-)
DBA/2J MGP_DBA2J_G0030752
 protein coding gene Chr6:80625388-80648390 (-)
FVB/NJ MGP_FVBNJ_G0030705
 protein coding gene Chr6:79833902-79857123 (-)
LP/J MGP_LPJ_G0030831
 protein coding gene Chr6:84527903-84554470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030741
 protein coding gene Chr6:94559112-94581812 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031396
 protein coding gene Chr6:83473650-83496406 (-)
PWK/PhJ MGP_PWKPhJ_G0029736
 protein coding gene Chr6:79531279-79554167 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029564
 protein coding gene Chr6:82323497-82346387 (-)
WSB/EiJ MGP_WSBEiJ_G0030102
 protein coding gene Chr6:83908654-83931379 (-)



Homology
more
  • Human Ortholog
    ACTG2, actin gamma 2, smooth muscle
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTG2, actin gamma 2, smooth muscle
  • Synonyms
    ACT, ACTA3, ACTE, ACTL3, ACTSG, MMIHS5, VSCM, VSCM1
  • Links
    NCBI Gene ID: 72
    neXtProt AC: NX_P63267
    UniProt: P63267

  • Chr Location
    2p13.1; chr2:73892314-73919865 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Actg2 mouse models; 1 with human ACTG2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    90
  • cDNA Data
    127
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11468 NCBI Gene Model | MGI Sequence Detail 23343 C57BL/6J ±  kb
    transcript NM_009610 RefSeq | MGI Sequence Detail 1341 ZRU/MplStud  
    polypeptide P63268 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      Genomic 5
      cDNA 128
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1075, MGD-MRK-1079, MGD-MRK-26023
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:9892 Kim E, et al., Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice. Mol Cell Biol. 1989 May;9(5):1875-81
    • Latest
      J:344876 Cai H, et al., Heterozygous Actg2(R257C) mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome. Neurogastroenterol Motil. 2023 Jan;35(1):e14472
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory