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Fgd1 Gene Detail
Summary
  • Symbol
    Fgd1
  • Name
    FYVE, RhoGEF and PH domain containing 1
  • Synonyms
    faciogenital dysplasia, ZFYVE3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104566
    NCBI Gene: 14163
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:149829146-149872517 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104566
 protein coding gene ChrX:149829141-149872682 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036174
 protein coding gene ChrX:148774444-148821521 (+)
A/J MGP_AJ_G0036150
 protein coding gene ChrX:147989288-148031799 (+)
AKR/J MGP_AKRJ_G0036076
 protein coding gene ChrX:152772150-152816416 (+)
BALB/cJ MGP_BALBcJ_G0036141
 protein coding gene ChrX:146180062-146223168 (+)
C3H/HeJ MGP_C3HHeJ_G0035849
 protein coding gene ChrX:148983639-149030169 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036666
 protein coding gene ChrX:152984019-153034000 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033490
 protein coding gene ChrX:139750312-139794776 (+)
CAST/EiJ MGP_CASTEiJ_G0035140
 protein coding gene ChrX:128434248-128470118 (+)
CBA/J MGP_CBAJ_G0035826
 protein coding gene ChrX:157533712-157577610 (+)
DBA/2J MGP_DBA2J_G0035984
 protein coding gene ChrX:147067561-147115879 (+)
FVB/NJ MGP_FVBNJ_G0035918
 protein coding gene ChrX:146213260-146256527 (+)
LP/J MGP_LPJ_G0036075
 protein coding gene ChrX:149859674-149903854 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035954
 protein coding gene ChrX:165622742-165668020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036701
 protein coding gene ChrX:148280963-148326183 (+)
PWK/PhJ MGP_PWKPhJ_G0034834
 protein coding gene ChrX:125395430-125439634 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034660
 protein coding gene ChrX:128884401-128926660 (+)
WSB/EiJ MGP_WSBEiJ_G0035275
 protein coding gene ChrX:146382634-146428522 (+)



Homology
more
  • Human Ortholog
    FGD1, FYVE, RhoGEF and PH domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGD1, FYVE, RhoGEF and PH domain containing 1
  • Synonyms
    AAS, FGDY, MRXS16, ZFYVE3
  • Links
    NCBI Gene ID: 2245
    neXtProt AC: NX_P98174
    UniProt: P98174

  • Chr Location
    Xp11.22; chrX:54445454-54496234 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FGD1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    58
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025265 Ensembl Gene Model | MGI Sequence Detail 43372 C57BL/6J ±  kb
    transcript ENSMUST00000026296 Ensembl | MGI Sequence Detail 4001 Not Applicable  
    polypeptide ENSMUSP00000026296 Ensembl | MGI Sequence Detail 960 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26000
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:26633 Pasteris NG, et al., Cloning and regional localization of the mouse faciogenital dysplasia (Fgd1) gene. Mamm Genome. 1995 Sep;6(9):658-61
    • Latest
      J:178465 Zou W, et al., MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov 1;121(11):4383-92
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory