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Apof Gene Detail
Summary
  • Symbol
    Apof
  • Name
    apolipoprotein F
  • Feature Type
    protein coding gene
  • IDs
    MGI:104539
    NCBI Gene: 103161
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128103866-128106022 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.50 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104539
 protein coding gene Chr10:128103866-128107119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017855
 protein coding gene Chr10:131983343-131985497 (+)
A/J MGP_AJ_G0017830
 protein coding gene Chr10:126689872-126692025 (+)
AKR/J MGP_AKRJ_G0017793
 protein coding gene Chr10:130414437-130416591 (+)
BALB/cJ MGP_BALBcJ_G0017794
 protein coding gene Chr10:127073089-127075243 (+)
C3H/HeJ MGP_C3HHeJ_G0017617
 protein coding gene Chr10:130563496-130565650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018249
 protein coding gene Chr10:136458986-136461140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015927
 protein coding gene Chr10:120626037-120628202 (+)
CAST/EiJ MGP_CASTEiJ_G0017178
 protein coding gene Chr10:131282674-131284838 (+)
CBA/J MGP_CBAJ_G0017587
 protein coding gene Chr10:141995201-141997355 (+)
DBA/2J MGP_DBA2J_G0017693
 protein coding gene Chr10:125753068-125755222 (+)
FVB/NJ MGP_FVBNJ_G0017688
 protein coding gene Chr10:124681699-124683853 (+)
LP/J MGP_LPJ_G0017767
 protein coding gene Chr10:132580709-132582863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017716
 protein coding gene Chr10:144596111-144598265 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018289
 protein coding gene Chr10:130507093-130509247 (+)
PWK/PhJ MGP_PWKPhJ_G0016963
 protein coding gene Chr10:126011016-126013177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016752
 protein coding gene Chr10:129597327-129599490 (+)
WSB/EiJ MGP_WSBEiJ_G0017237
 protein coding gene Chr10:130725886-130728040 (+)



Homology
more
  • Human Ortholog
    APOF, apolipoprotein F
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOF, apolipoprotein F
  • Synonyms
    Apo-F, LTIP
  • Links
    NCBI Gene ID: 319
    neXtProt AC: NX_Q13790
    UniProt: Q13790

  • Chr Location
    12q13.3; chr12:56360568-56362857 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired ABCG1-mediated cholesterol efflux.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    21
  • cDNA Data
    60
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047631 Ensembl Gene Model | MGI Sequence Detail 2157 C57BL/6J ±  kb
    transcript ENSMUST00000238970 Ensembl | MGI Sequence Detail 1930 Not Applicable  
    polypeptide ENSMUSP00000158988 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 60

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-25971, MGI:2143547
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:34160 Gwynn B, et al., Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Genomics. 1996 Jul 15;35(2):389-91
    • Latest
      J:236757 West DB, et al., Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet. 2016 Feb;12(2):e1005691
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory