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Grb10 Gene Detail
Summary
  • Symbol
    Grb10
  • Name
    growth factor receptor bound protein 10
  • Synonyms
    5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207
  • Feature Type
    protein coding gene
  • IDs
    MGI:103232
    NCBI Gene: 14783
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:11880499-11987428 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 7.15 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103232
 protein coding gene Chr11:11880499-11988683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018048
 protein coding gene Chr11:9241721-9353448 (-)
A/J MGP_AJ_G0018021
 protein coding gene Chr11:8910988-9020151 (-)
AKR/J MGP_AKRJ_G0017985
 protein coding gene Chr11:9285623-9396453 (-)
BALB/cJ MGP_BALBcJ_G0017989
 protein coding gene Chr11:8942351-9050492 (-)
C3H/HeJ MGP_C3HHeJ_G0017802
 protein coding gene Chr11:9186505-9294477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018441
 protein coding gene Chr11:9551231-9662406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016099
 protein coding gene Chr11:8459356-8565160 (-)
CAST/EiJ MGP_CASTEiJ_G0017364
 protein coding gene Chr11:9198347-9309843 (-)
CBA/J MGP_CBAJ_G0017777
 protein coding gene Chr11:10239503-10349525 (-)
DBA/2J MGP_DBA2J_G0017887
 protein coding gene Chr11:8839666-8948114 (-)
FVB/NJ MGP_FVBNJ_G0017879
 protein coding gene Chr11:8755023-8863077 (-)
LP/J MGP_LPJ_G0017958
 protein coding gene Chr11:9346525-9462482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017905
 protein coding gene Chr11:9963336-10073879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018482
 protein coding gene Chr11:9320704-9430471 (-)
PWK/PhJ MGP_PWKPhJ_G0017144
 protein coding gene Chr11:8877348-8987512 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016941
 protein coding gene Chr11:9153849-9273567 (-)
WSB/EiJ MGP_WSBEiJ_G0017418
 protein coding gene Chr11:9067260-9180465 (-)



Homology
more
  • Human Ortholog
    GRB10, growth factor receptor bound protein 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRB10, growth factor receptor bound protein 10
  • Synonyms
    Grb-10, GRB-IR, IRBP, MEG1, RSS
  • Links
    NCBI Gene ID: 2887
    neXtProt AC: NX_Q13322
    UniProt: Q13322

  • Chr Location
    7p12.1; chr7:50590063-50793462 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Maternal transmission of a mutant allele results in both fetal and placental overgrowth. Disproportionate overgrowth of the liver is observed. Paternal transmission of an allele lacking the differentially methylated region results in growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1330
  • Tissues
    131
  • cDNA Data
    37
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14783 NCBI Gene Model | MGI Sequence Detail 106930 C57BL/6J ±  kb
    transcript NM_001370603 RefSeq | MGI Sequence Detail 5164 ZRU/MplStud  
    polypeptide Q60760 UniProt | EBI | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 42
      Primer pair 15
      Other 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24105, MGI:1915227, MGI:2144128
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 47
      Diseases 1
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:24927 Ooi J, et al., The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene. 1995 Apr 20;10(8):1621-30
    • Latest
      J:341789 Liu H, et al., Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nat Metab. 2023 Jan;5(1):147-164
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory