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Cyp4b1 Gene Detail
Summary
  • Symbol
    Cyp4b1
  • Name
    cytochrome P450, family 4, subfamily b, polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103225
    NCBI Gene: 13120
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115481922-115504920 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103225
 protein coding gene Chr4:115481895-115504920 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028605
 protein coding gene Chr4:116459121-116483029 (-)
A/J MGP_AJ_G0028566
 protein coding gene Chr4:112027651-112049213 (-)
AKR/J MGP_AKRJ_G0028515
 protein coding gene Chr4:114423990-114460760 (-)
BALB/cJ MGP_BALBcJ_G0028587
 protein coding gene Chr4:112639983-112663549 (-)
C3H/HeJ MGP_C3HHeJ_G0028301
 protein coding gene Chr4:115970911-116005189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029028
 protein coding gene Chr4:120976160-120998279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026312
 protein coding gene Chr4:106115707-106138297 (-)
CAST/EiJ MGP_CASTEiJ_G0027736
 protein coding gene Chr4:113234378-113253164 (-)
CBA/J MGP_CBAJ_G0028268
 protein coding gene Chr4:124233650-124274038 (-)
DBA/2J MGP_DBA2J_G0028416
 protein coding gene Chr4:112674683-112698505 (-)
FVB/NJ MGP_FVBNJ_G0028384
 protein coding gene Chr4:111173090-111201002 (-)
LP/J MGP_LPJ_G0028516
 protein coding gene Chr4:116600089-116732175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028411
 protein coding gene Chr4:129305573-129331467 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029065
 protein coding gene Chr4:115592762-115621390 (-)
PWK/PhJ MGP_PWKPhJ_G0027461
 protein coding gene Chr4:109439840-109468073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027284
 protein coding gene Chr4:111823425-111857822 (-)
WSB/EiJ MGP_WSBEiJ_G0027814
 protein coding gene Chr4:115431250-115456526 (-)



Homology
more
  • Human Ortholog
    CYP4B1, cytochrome P450 family 4 subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP4B1, cytochrome P450 family 4 subfamily B member 1
  • Synonyms
    CYPIVB1, P-450HP
  • Links
    NCBI Gene ID: 1580
    neXtProt AC: NX_P13584
    UniProt: P13584

  • Chr Location
    1p33; chr1:46757838-46819413 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to 4-ipomeanol activation and toxicity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    13
  • cDNA Data
    272
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028713 Ensembl Gene Model | MGI Sequence Detail 22999 C57BL/6J ±  kb
    transcript ENSMUST00000102707 Ensembl | MGI Sequence Detail 1892 Not Applicable  
    polypeptide ENSMUSP00000099768 Ensembl | MGI Sequence Detail 511 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 274
      Genomic 1
      cDNA 272
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24096
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:27761 Imaoka S, et al., Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1. Arch Biochem Biophys. 1995 Aug 1;321(1):255-62
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory