About   Help   FAQ
Mcm5 Gene Detail
Summary
  • Symbol
    Mcm5
  • Name
    minichromosome maintenance complex component 5
  • Synonyms
    Cdc46, mCD46, Mcmd5
  • Feature Type
    protein coding gene
  • IDs
    MGI:103197
    NCBI Gene: 17218
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75836197-75855067 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103197
 protein coding gene Chr8:75836096-75855067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033796
 protein coding gene Chr8:75569705-75588641 (+)
A/J MGP_AJ_G0033778
 protein coding gene Chr8:72595037-72613955 (+)
AKR/J MGP_AKRJ_G0033705
 protein coding gene Chr8:74809844-74830471 (+)
BALB/cJ MGP_BALBcJ_G0033772
 protein coding gene Chr8:72694945-72713881 (+)
C3H/HeJ MGP_C3HHeJ_G0033481
 protein coding gene Chr8:75369915-75388851 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034292
 protein coding gene Chr8:78496882-78516994 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031233
 protein coding gene Chr8:66860991-66882555 (+)
CAST/EiJ MGP_CASTEiJ_G0032810
 protein coding gene Chr8:74649162-74668930 (+)
CBA/J MGP_CBAJ_G0033460
 protein coding gene Chr8:81255786-81274718 (+)
DBA/2J MGP_DBA2J_G0033614
 protein coding gene Chr8:72287558-72306493 (+)
FVB/NJ MGP_FVBNJ_G0033559
 protein coding gene Chr8:71360825-71380181 (+)
LP/J MGP_LPJ_G0033703
 protein coding gene Chr8:75696294-75715379 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033602
 protein coding gene Chr8:83813057-83831972 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034309
 protein coding gene Chr8:74773343-74792279 (+)
PWK/PhJ MGP_PWKPhJ_G0032516
 protein coding gene Chr8:71554297-71573920 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032354
 protein coding gene Chr8:73663034-73681937 (+)
WSB/EiJ MGP_WSBEiJ_G0032925
 protein coding gene Chr8:75080982-75099678 (+)



Homology
more
  • Human Ortholog
    MCM5, minichromosome maintenance complex component 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM5, minichromosome maintenance complex component 5
  • Synonyms
    CDC46, MGORS8, P1-CDC46
  • Links
    NCBI Gene ID: 4174
    neXtProt AC: NX_P33992
    UniProt: P33992

  • Chr Location
    22q12.3; chr22:35400134-35455031 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MCM5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    159
  • cDNA Data
    272
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005410 Ensembl Gene Model | MGI Sequence Detail 18871 C57BL/6J ±  kb
    transcript ENSMUST00000164309 Ensembl | MGI Sequence Detail 3381 Not Applicable  
    polypeptide ENSMUSP00000126135 Ensembl | MGI Sequence Detail 734 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 277
      Genomic 1
      cDNA 272
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24065, MGI:2142437, MGI:2142508, MGI:2142670
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:26776 Kimura H, et al., Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Nucleic Acids Res. 1995 Jun 25;23(12):2097-104
    • Latest
      J:336417 Chong D, et al., Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory