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Stat1 Gene Detail
Summary
  • Symbol
    Stat1
  • Name
    signal transducer and activator of transcription 1
  • Synonyms
    2010005J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103063
    NCBI Gene: 20846
  • Alliance
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52158599-52201024 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.81 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103063
protein coding gene Chr1:52158588-52201024 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016006
protein coding gene Chr1:51628850-51671784 (+)
A/J MGP_AJ_G0015988
protein coding gene Chr1:49900289-49942002 (+)
AKR/J MGP_AKRJ_G0015944
protein coding gene Chr1:50952889-50994736 (+)
BALB/cJ MGP_BALBcJ_G0015945
protein coding gene Chr1:49715568-49757744 (+)
C3H/HeJ MGP_C3HHeJ_G0015777
protein coding gene Chr1:51359021-51402478 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016396
protein coding gene Chr1:53800977-53842750 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014128
protein coding gene Chr1:41915041-41956718 (-)
CAST/EiJ MGP_CASTEiJ_G0015358
protein coding gene Chr1:50840041-50881813 (+)
CBA/J MGP_CBAJ_G0015748
protein coding gene Chr1:55235992-55277729 (+)
DBA/2J MGP_DBA2J_G0015849
protein coding gene Chr1:49151562-49193563 (+)
FVB/NJ MGP_FVBNJ_G0015851
protein coding gene Chr1:48616606-48658312 (+)
LP/J MGP_LPJ_G0015920
protein coding gene Chr1:52125262-52166698 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015871
protein coding gene Chr1:58262387-58305563 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016444
protein coding gene Chr1:51084199-51125904 (+)
PWK/PhJ MGP_PWKPhJ_G0015144
protein coding gene Chr1:49032952-49074196 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014924
protein coding gene Chr1:50737870-50779590 (+)
WSB/EiJ MGP_WSBEiJ_G0015421
protein coding gene Chr1:50889963-50936974 (+)



Homology
more
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
  • Synonyms
    CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
  • Links
    NCBI Gene ID: 6772
    neXtProt AC: NX_P42224
    UniProt: P42224

  • Chr Location
    2q32.2; chr2:190908460-191020960 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Stat1 mouse models; 6 with human STAT1 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 15 alleles in 23 genetic backgrounds
    30 phenotypes from multigenic genotypes
    517 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026104 Ensembl Gene Model | MGI Sequence Detail 42426 C57BL/6J ±  kb
    transcript ENSMUST00000186057 Ensembl | MGI Sequence Detail 3998 Not Applicable  
    polypeptide ENSMUSP00000141132 Ensembl | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000002087 signal transducer and activator of transcription 1
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
      IPR048988 Signal transducer and activator of transcription, linker domain
      IPR038295 STAT1, C-terminal domain superfamily
      IPR035859 STAT1, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 7
      cDNA 25
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23925, MGI:1923977, MGI:2138078
    References
    more
    • Summaries
      All 787
      Developmental Gene Expression 44
      Diseases 3
      Gene Ontology 24
      Phenotypes 517
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345253 Zhang Y, et al., HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression. Nat Commun. 2024 Feb 13;15(1):1314

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory