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Tpp2 Gene Detail
Summary
  • Symbol
    Tpp2
  • Name
    tripeptidyl peptidase II
  • Synonyms
    TppII
  • Feature Type
    protein coding gene
  • IDs
    MGI:102724
    NCBI Gene: 22019
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43973130-44042160 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102724
 protein coding gene Chr1:43972807-44042160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015983
 protein coding gene Chr1:42970086-43040660 (+)
A/J MGP_AJ_G0015967
 protein coding gene Chr1:41635648-41704565 (+)
AKR/J MGP_AKRJ_G0015922
 protein coding gene Chr1:42208397-42281463 (+)
BALB/cJ MGP_BALBcJ_G0015921
 protein coding gene Chr1:41318696-41388147 (+)
C3H/HeJ MGP_C3HHeJ_G0015754
 protein coding gene Chr1:42589958-42658859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016374
 protein coding gene Chr1:44687145-44773897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014096
 protein coding gene Chr1:38474218-38545524 (+)
CAST/EiJ MGP_CASTEiJ_G0015335
 protein coding gene Chr1:42596142-42679953 (+)
CBA/J MGP_CBAJ_G0015726
 protein coding gene Chr1:45997330-46072029 (+)
DBA/2J MGP_DBA2J_G0015827
 protein coding gene Chr1:40926114-41009400 (+)
FVB/NJ MGP_FVBNJ_G0015829
 protein coding gene Chr1:40441285-40510133 (+)
LP/J MGP_LPJ_G0015897
 protein coding gene Chr1:43287582-43357946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015849
 protein coding gene Chr1:47972466-48052928 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016421
 protein coding gene Chr1:42428500-42501016 (+)
PWK/PhJ MGP_PWKPhJ_G0015118
 protein coding gene Chr1:40813238-40884155 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014900
 protein coding gene Chr1:42446532-42526109 (+)
WSB/EiJ MGP_WSBEiJ_G0015397
 protein coding gene Chr1:42475874-42547534 (+)



Homology
more
  • Human Ortholog
    TPP2, tripeptidyl peptidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPP2, tripeptidyl peptidase 2
  • Synonyms
    IMD78, TPP-2, TPPII, TPP-II
  • Links
    NCBI Gene ID: 7174
    neXtProt AC: NX_P29144
    UniProt: P29144

  • Chr Location
    13q33.1; chr13:102596958-102679958 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TPP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    181
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22019 NCBI Gene Model | MGI Sequence Detail 69031 C57BL/6J ±  kb
    transcript NM_009418 RefSeq | MGI Sequence Detail 4708 ZRU/MplStud  
    polypeptide Q64514 UniProt | EBI | MGI Sequence Detail 1262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000016586 tripeptidyl-peptidase 2
      (term hierarchy)
    • EC
      3.4.14.10
    • InterPro Domains
      IPR000209 Peptidase S8/S53 domain
      IPR036852 Peptidase S8/S53 domain superfamily
      IPR022398 Peptidase S8, subtilisin, His-active site
      IPR015500 Peptidase S8, subtilisin-related
      IPR023828 Peptidase S8, subtilisin, Ser-active site
      IPR046939 Tripeptidyl-peptidase 2, C-terminal domain superfamily
      IPR022232 Tripeptidyl peptidase II, C-terminal domain, arthropoda
      IPR034051 Tripeptidyl-peptidase II domain
      IPR048383 Tripeptidyl-peptidase II, first Ig-like domain
      IPR048384 Tripeptidyl-peptidase II, galactose-binding domain-like
      IPR046940 Tripeptidyl peptidase II, Ig-like domain superfamily
      IPR022229 Tripeptidyl peptidase II, second Ig-like domain
    Molecular
    Reagents
    less
    • All nucleic 185
      Genomic 1
      cDNA 184

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19628
    References
    more
    • Summaries
      All 50
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:2944 Epstein DJ, et al., Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 1991 Nov 15;67(4):767-74
    • Latest
      J:345615 Zhao J, et al., Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1. Theranostics. 2024;14(4):1390-1429
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory