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Mtcp1 Gene Detail
Summary
  • Symbol
    Mtcp1
  • Name
    mature T cell proliferation 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102699
    NCBI Gene: 17763
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:74454048-74460190 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.22 cM
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102699
 protein coding gene ChrX:74454048-74460194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035859
 protein coding gene ChrX:71254550-71260704 (-)
A/J MGP_AJ_G0035846
 protein coding gene ChrX:71475327-71481469 (-)
AKR/J MGP_AKRJ_G0035767
 protein coding gene ChrX:73329537-73335659 (-)
BALB/cJ MGP_BALBcJ_G0035828
 protein coding gene ChrX:70467597-70473721 (-)
C3H/HeJ MGP_C3HHeJ_G0035538
 protein coding gene ChrX:71753880-71760022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036358
 protein coding gene ChrX:73533838-73539968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033197
 protein coding gene ChrX:70986175-70992224 (-)
CAST/EiJ MGP_CASTEiJ_G0034824
 protein coding gene ChrX:57084494-57090642 (-)
CBA/J MGP_CBAJ_G0035511
 protein coding gene ChrX:75498955-75505083 (-)
DBA/2J MGP_DBA2J_G0035669
 protein coding gene ChrX:70928582-70934712 (-)
FVB/NJ MGP_FVBNJ_G0035610
 protein coding gene ChrX:70254055-70260171 (-)
LP/J MGP_LPJ_G0035751
 protein coding gene ChrX:72055222-72062358 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035644
 protein coding gene ChrX:78113051-78119176 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036384
 protein coding gene ChrX:71122553-71128685 (-)
PWK/PhJ MGP_PWKPhJ_G0034521
 protein coding gene ChrX:55087978-55094101 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034357
 protein coding gene ChrX:57884909-57891096 (-)
WSB/EiJ MGP_WSBEiJ_G0034963
 protein coding gene ChrX:70327648-70333795 (-)



Homology
more
  • Human Ortholog
    CMC4, C-X9-C motif containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMC4, C-X9-C motif containing 4
  • Synonyms
    C6.1B, MTCP1, MTCP1B, MTCP1NB, p8, p8MTCP1
  • Links
    NCBI Gene ID: 100272147
    neXtProt AC: NX_P56277
    UniProt: P56277

  • Chr Location
    Xq28; chrX:155061622-155071136 (-)  GRCh38
  • Human Ortholog
    MTCP1, mature T cell proliferation 1
  • Synonyms
    P13MTCP1, p8MTCP1, TCL1C
  • Links
    NCBI Gene ID: 4515
    neXtProt AC: NX_P56278
    UniProt: P56278

  • Chr Location
    Xq28; chrX:155064034-155147937 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    51
  • cDNA Data
    23
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17763 NCBI Gene Model | MGI Sequence Detail 6143 C57BL/6J ±  kb
transcript NM_001039373 RefSeq | MGI Sequence Detail 1635 C57BL/6  
polypeptide Q60945 UniProt | EBI | MGI Sequence Detail 107 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-19603
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:21838 Soulier J, et al., The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. Oncogene. 1994 Dec;9(12):3565-70
  • Latest
    J:314701 Walker JS, et al., Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia. Nat Commun. 2021 Nov 3;12(1):6338
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory