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Pou4f2 Gene Detail
Summary
  • Symbol
    Pou4f2
  • Name
    POU domain, class 4, transcription factor 2
  • Synonyms
    Brn-3.2, Brn3b, Brn-3b, mBrn3-3R, Pou4f-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102524
    NCBI Gene: 18997
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:79159639-79163274 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 36.99 cM, cytoband F1-F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102524
protein coding gene Chr8:79159638-79163276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033805
protein coding gene Chr8:79048683-79052318 (-)
A/J MGP_AJ_G0033787
protein coding gene Chr8:75891967-75895602 (-)
AKR/J MGP_AKRJ_G0033714
protein coding gene Chr8:78174637-78178272 (-)
BALB/cJ MGP_BALBcJ_G0033781
protein coding gene Chr8:76003275-76006910 (-)
C3H/HeJ MGP_C3HHeJ_G0033490
protein coding gene Chr8:78784062-78787697 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034301
protein coding gene Chr8:82066009-82069644 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031242
protein coding gene Chr8:69991545-69995186 (-)
CAST/EiJ MGP_CASTEiJ_G0032821
protein coding gene Chr8:78128471-78132100 (-)
CBA/J MGP_CBAJ_G0033469
protein coding gene Chr8:84986799-84990434 (-)
DBA/2J MGP_DBA2J_G0033623
protein coding gene Chr8:75590928-75594563 (-)
FVB/NJ MGP_FVBNJ_G0033568
protein coding gene Chr8:74584153-74586477 (-)
LP/J MGP_LPJ_G0033712
protein coding gene Chr8:79124711-79128346 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033611
protein coding gene Chr8:87583009-87586644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034318
protein coding gene Chr8:78179820-78183455 (-)
PWK/PhJ MGP_PWKPhJ_G0032525
protein coding gene Chr8:74864509-74868139 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032363
protein coding gene Chr8:77028693-77032327 (-)
WSB/EiJ MGP_WSBEiJ_G0032934
protein coding gene Chr8:78514319-78517954 (-)



Homology
more
  • Human Ortholog
    POU4F2, POU class 4 homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU4F2, POU class 4 homeobox 2
  • Synonyms
    BRN3.2, Brn-3b, BRN3B
  • Links
    NCBI Gene ID: 5458
    neXtProt AC: NX_Q12837
    UniProt: Q12837

  • Chr Location
    4q31.22; chr4:146638893-146642474 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 11 alleles in 13 genetic backgrounds
    23 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have a 70% reduction in retinal ganglion cells, a thin retina, and an optic nerve with a decreased diameter and disorganized axons. Eyes have miotic pupils and defective optokinetic reflexes that prevent photo-entrainment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031688 Ensembl Gene Model | MGI Sequence Detail 3636 C57BL/6J ±  kb
    transcript ENSMUST00000034115 Ensembl | MGI Sequence Detail 3204 Not Applicable  
    polypeptide ENSMUSP00000034115 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 8
      cDNA 17
      Primer pair 11
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1631, MGD-MRK-19368, MGD-MRK-19462, MGI:102576
    References
    more
    • Summaries
      All 301
      Developmental Gene Expression 221
      Gene Ontology 32
      Phenotypes 72
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:343468 Li Y, et al., Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms. iScience. 2023 Dec 15;26(12):108544

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory