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mt-Co3 Gene Detail
Summary
  • Symbol
    mt-Co3
  • Name
    mitochondrially encoded cytochrome c oxidase III
  • Synonyms
    COIII, COX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:102502
    NCBI Gene: 17710
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrMT:8607-9390 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome MT, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102502
 protein coding gene ChrMT:8607-9390 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COX3, cytochrome c oxidase subunit III
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX3, cytochrome c oxidase subunit III
  • Synonyms
    COIII, MTCO3
  • Links
    NCBI Gene ID: 4514
    neXtProt AC: NX_P00414
    UniProt: P00414

  • Chr Location
    chrMT:9207-9990 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COX3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    118
  • cDNA Data
    8
  • Literature Summary
    8
Sequences &
Gene Models
less
  • All Sequences
    60
  • RefSeq
    1
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic 17710 NCBI Gene Model | MGI Sequence Detail 784 C57BL/6J ±  kb
transcript BC012020 GenBank | ENA | DDBJ | MGI Sequence Detail 1616 C57BL/6  
polypeptide P00416 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    cDNA 10
    Primer pair 1
    Other 53
Other
Accession IDs
less
MGD-MRK-19339, MGI:2138394, MGI:2138420, MGI:2138462, MGI:2138508
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:333724 Park EJ, et al., Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory